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Att forma sitt rum : fullskalemodellering i participatoriska designprocesser

Architects design work sometimes originates from a simplified view of human demands and needs, which may result in environments that do not fulfill the users requirements. This thesis refers to five different case studies where the affected users were involved in the creation of their dwellings or working environment. The issue of the thesis is that participatory design creates environments which

Mastarbete i kyla

En fältstudie på åtta mastarbetare utfördes under februari i Svealand och Norrland. Mastarbetarnas aktiviteter observerades under en vanlig arbetsdag i masten och hudtemperaturen på sju ställen på kroppen, kroppstemperatur och hjärtfrekvens registrerades kontinuerligt. De fick också skatta sin temperaturupplevelse och ansträngningsgrad flera gånger under dagen. Lufttemperaturen varierade mellan -1

A comparison of customer perceived service quality in discount versus traditional grocery stores.

Purpose -- The overall purpose of this study is to enhance the understanding of customer perceived service quality within grocery retailing in a North European context. We do this by comparing customer perceived service quality evaluations of the traditional supermarket store with evaluations of the discount store. Design/methodology/approach -- This study is based on empirical data from four stor

Development and evaluation of the aerosol dynamics and gas phase chemistry model ADCHEM

The aim of this work was to develop a model suited for detailed studies of aerosol dynamics, gas and particle phase chemistry within urban plumes, from local scale (1x1 km(2)) to regional scale. This article describes and evaluates the trajectory model for Aerosol Dynamics, gas and particle phase CHEMistry and radiative transfer (AD-CHEM). The model treats both vertical and horizontal dispersion p

Safety, tolerability, and antibody response of active A beta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,

The importance of emotional distress, cognitive behavioural factors and pain for life impact at baseline and for outcomes after rehabilitation - A SQRP study of more than 20,000 chronic pain patients

Although literature concerning chronic pain patients indicates that cognitive behavioural variables, specifically acceptance and fear of movement/(re)injury, are related to life impact, the relative roles of these factors in relation to pain characteristics (e.g. intensity and spreading) and emotional distress are unclear. Moreover, how these variables affect rehabilitation outcomes in different s

Classical and Delayed Orthostatic Hypotension in Patients With Unexplained Syncope and Severe Orthostatic Intolerance

Background: Orthostatic hypotension (OH) is a major sign of cardiovascular autonomic failure leading to orthostatic intolerance and syncope. Orthostatic hypotension is traditionally divided into classical OH (cOH) and delayed OH (dOH), but the differences between the two variants are not well-studied. We performed a systematic clinical and neuroendocrine characterization of OH patients in a tertia

Restraint Effects in Concrete Bridges : A Study of Cracking due to Thermal Actions and Shrinkage in Portal Frame Bridges

Temperaturändringar och krympning påverkar betongkonstruktioners volym, och i konstruktioner som hindras från av röra sig kan sådana volymändringar leda till så kallade tvångseffekter, som i sin tur kan orsaka sprickbildning. När detta sker kan emellertid konstruktionen deformeras till viss del, vilket gör att tvångsspänningarna och därmed också sprickvidderna minskar. Uppsprickningsförloppet är sThermal actions and shrinkage cause volume changes in concrete structures. In structures which are restrained from movements, the restraint effects can cause cracking. However, when cracking occurs, the structure can deform to some extent, which reduces the restraint stresses and thus also the crack widths. As the exact crack development is hard to predict beforehand, the actual restraint and thus

Psychiatric diagnoses in older people with intellectual disability in comparison with the general population a register study

AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population.METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regar

Burkitt lymphoma and diffuse large B-cell lymphoma – therapeutic strategies and pathogenetic mechanisms

Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti

Sustainable Supply Chain Management in Food Retailing : Insights into corporate practice of managing supplier relationships

Addressing sustainability concerns in supply chain operations can be a matter of long-term business survival for food retailers. However, regardless of whether it is perceived as a risk or market opportunity, acting across the value chain to address unsustainable production and consumption practices has been a constant challenge. This thesis investigated the sustainable supply chain management (SS

Versform & ikonicitet : Med exempel från svensk modernistisk lyrik

Thisthesis revisits and explores the relationship between verse and meaning bymeans of the notion of iconicity, i.e.,as signs primarily based on similarity. The aim of the thesis is to show howverse and its interaction with words and sentences create meaning and can be anintegrated part in the interpretation or understanding of the poem as a whole.Verse is discussed in relation to four other liter

Political comedy engagement : Genre work, political identity and cultural citizenship

Politisk komedi är en hybridgenre där politiska nyheter och analyser blandas med komedi och underhållning. Allt eftersom politisk komedi ökar i popularitet – i de flesta medieformer och nationella kontexter – arbetar forskare med att förstå dess roll i relation till medborgarskap, och det kan konstateras att genren utmanar den vetenskapliga förståelsen av politiska medier och medborgarskap. Denna Political comedy is a hybrid genre that mixes political news and analysis with comedy and entertainment. As it becomes more and more popular in most media forms and national contexts, researchers struggle to understand its role in relation to other types of political media, and of citizenship; in this sense, it challenges scholarly conceptualisation of political media and citizenship. Thus, this t

Diet and postmenopausal breast cancer - With a focus on low-grade inflammation

Diet-breast cancer studies have shown that “healthy eating patterns” are associated with decreased risk whereas unhealthy patterns (especially those including alcohol) are associated with increased risk, particularly in postmenopausal women. The potential mechanisms behind the observed associations are still under investigation. A great deal of evidence supports the major role of lifelong overexpo

Early- versus Late-Onset Alzheimer’s Disease—Differences in Functional Impairment.

Background: Persons with clinical onset of Alzheimer’s disease (AD) before 65 years of age are diagnosed with early-onset AD (EOAD). The prevalence of EOAD is low, but varies among studies from 6% to 16%. Most individuals with EOAD are still working, have an active social life, and might have children living at home. Therefore, the consequences of being diagnosed early with a disease that implies

The void : Urban wasteland as political space

The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a def

ω-3 Polyunsaturated fatty acid biomarkers and coronary heart disease : Pooling project of 19 cohort studies

Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. Objective: To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) an