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Diet-breast cancer studies have shown that “healthy eating patterns” are associated with decreased risk whereas unhealthy patterns (especially those including alcohol) are associated with increased risk, particularly in postmenopausal women. The potential mechanisms behind the observed associations are still under investigation. A great deal of evidence supports the major role of lifelong overexpo
AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population.METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regar
Proficiency in writing is a central graduate attribute of higher education. In practice, this means that students are expected to acquire both generic and discipline-specific writing skills that will be beneficial for their professional lives. Although the learning outcomes for many courses include the ability to express oneself in writing, a predominant function of writing is that of mere testing
This thesis consists of five papers on different aspects of parametervariation in some common exchange rate models.The first paper investigates the stability in the real exchange rate, witch is equivalent to purchasing power parity (PPP). In recent empirical literature on purchasing power parity, the focus has been on the stationarity of real exchange rates, instead of strict constancy. Earlier st
This thesis deals with students' constructions of mathematical knowledge in the case of fractions from a radical constructivist perspective. Fractions are the first more abstracted mathematics met by students. Even if they have a rich experience of sharing and partitioning things in their everyday life dealing with fractions often give rise to difficulties in school. The thesis consists of two p
En fältstudie på åtta mastarbetare utfördes under februari i Svealand och Norrland. Mastarbetarnas aktiviteter observerades under en vanlig arbetsdag i masten och hudtemperaturen på sju ställen på kroppen, kroppstemperatur och hjärtfrekvens registrerades kontinuerligt. De fick också skatta sin temperaturupplevelse och ansträngningsgrad flera gånger under dagen. Lufttemperaturen varierade mellan -1
Architects design work sometimes originates from a simplified view of human demands and needs, which may result in environments that do not fulfill the users requirements. This thesis refers to five different case studies where the affected users were involved in the creation of their dwellings or working environment. The issue of the thesis is that participatory design creates environments which
Aims/hypothesis: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. Methods: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ litterma
Background: Regimens based on ibrutinib alone and lenalidomide and rituximab in combination show high activity in patients with relapsed or refractory mantle cell lymphoma. We hypothesised that the combination of all three drugs would improve efficacy compared with previously published data on either regimen alone. Methods: In this multicentre, open-label, single-arm, phase 2 trial, we enrolled pa
Background: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer. Methods: We applied a recently described five-strata model, the Cambridge Prognostic Groups (CPGs 1-5), in two international cohorts and tested prognostic performance against the curren
Jordens plattektoniska rörelser leder till tektoniska skeenden vid plattgränserna, bland annat bergskedjebildning, då berggrunden utsätts för förändringar i tryck och temperatur. Vid ändrat tryck och ändrad temperatur förändras också bergarter: de ursprungliga mineralen konsumeras i kemiska reaktioner och i stället bildas nya mineral som är stabila vid de nya fysikaliska förhållandena - en processDating of metamorphic events is crucial for the understanding and reconstruction of large-scale geological processes such as orogenesis. Zircon is one of the most commonly used minerals for dating of igneous and metamorphic events. Zircon incorporates uranium and excludes lead during crystallization, and with time the uranium decays to lead. The diffusion rates of both elements are slow, making zi
Vi har lyckan att leva i en föränderlig värld, och med förändringar följer variation. Den stora variationen i yttre egenskaper hos djur, och i synnerhet deras färger, fascinerar både forskare och lekmän. I den här avhandlingen utforskar jag flera aspekter på varför, och hur, färgvariation evolverar hos en karismatisk insektsgrupp. Dammflicksländor är färgglada, dagaktiva och visuellt drivna organiSexual conflict over mating shapes the interactions between males and females in many animals and is also responsible for dramatic adaptations in both sexes. In some species of pond damselflies (Odonata:Coeangrionidae), sexual conflict maintains discrete female-limited colour morphs over multiple generations and within populations. One of the female morphs is typically male-coloured and considered
The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer pat
GRASP (Group and Social Psychology) is an interdisciplinary conference, which aims to provide a community around social psychological issues for researchers, practitioners, and graduate students from the Nordic countries within the fields of psychology, sociology, education, behavioural sciences and social work to share, exchange, learn, and develop preliminary results, new concepts, ideas, princi
Aims/hypothesis: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome activation. C4b-binding protein (C4BP), present in serum, binds to IAPP and affect
Background: The prognosis of Alzheimer’s disease (AD) might be influenced by many sociodemographic and clinical factors. Previous studies have investigated the main effects of critical predictors but few have analyzed potential interactions. We have studied the long-term cognitive outcome, nursing home placement (NHP) and mortality by interactions between factors in cholinesterase inhibitor (ChEI)
