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As buildings become more energy-efficient in their operation, the environmental costs of building components, such as carbon emissions during manufacturing, transportation, and end-of-life, are becoming increasingly significant. Automated façade shading systems have been widely proposed for their ability to reduce operational energy use and improve daylight performance. However, their life-cycle e
This thesis examines how autonomous buses are interpreted and evaluated as a potential mobility solution within a multi-level planning context involving both municipal and regional perspectives. While autonomous vehicles are often framed as a key component of future sustainable transport systems, their implementation depends not only on technological development but also on social acceptance, inst
Artificial intelligence (AI) is playing an expanding role in infectious disease surveillance and intervention planning by enabling analysis of large-scale health data. One of the key challenges in this area is to characterize transmission within households and to identify factors that influence both infectivity and susceptibility. The present study focuses on the COVID-19 pandemic, which not only
GROWTH. reconsiders the notion of growth in architecture, not as a process of continuous expansion, but as a cyclical condition of emergence, stabilization, decay, and regeneration observed in natural ecosystems. Positioned between regenerative agriculture, computational design, and material-driven architectural practice, the thesis investigates how the growth cycles of biotic materials can become
Milk protein compositions play a pivotal role in physicochemical and technological properties of milk, particularly in rennet coagulation in cheese production. Conventional analytical methods such as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography–high resolution mass spectrometry (LC-HRMS) provide detailed protein characterization but require long an
Denna uppsats prövar den enskildes rättsliga ställning i en automatiserad förvaltning genom att analysera hur myndighetsövergripande beslutsmodeller förhåller sig till dataskyddsförordningens krav på skydd mot automatiserat beslutsfattande. Analysen genomförs med utgångspunkt i ett rättssäkerhetsperspektiv och har särskilt fokus på hur automatiserad profilering i ett inledande led samverkar med efThis thesis examines the legal position of the individual in an automated public administration by analyzing to what extent fragmented decision-making models can be reconciled with the requirements of the General Data Protection Regulation (GDPR) regarding protection against automated decision-making. The analysis is conducted from a legal certainty perspective and focuses in particular on how aut
Environmental claims have become a familiar feature of fashion marketing. On social media, however, they are rarely communicated in isolation. A state ment about recycled materials may appear alongside personal styling, aesthetic imagery and an influencer's endorsement. The challenge for EU consumer law is that the environmental meaning of such content may not lie in the wording alone, but in
The European Union's Nature Restoration Law aims to protect and restore the EU's ecosystems, among which specific target goals were set for urban ecosystems. This requires local authorities to assess and monitor urban tree cover (UTC), supported by strategic urban vegetation planning. As urban trees provide various benefits, including microclimate regulation, incorporating urban microclima
When greenhouse gas emissions in the building sector are considered, the focus is often on new construction. However, this is not the whole picture. Existing commercial buildings, such as office buildings, also go through several changes during their lifetime, and these changes can have a relevant climate impact. In office buildings, such changes are often called tenant adaptations, where the inte
Background and Objectives – Pyruvate dehydrogenase complex (PDHc) deficiency is a potentially treatable neurodegenerative genetic disorder. It represents a common cause of mitochondrial disease. Most published reports are limited to single cases, and population-based data are lacking. The objective of this study was to investigate the prevalence, incidence, and life expectancy and to explore genot
Background – While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mislocalization leads to cryptic exon inclusion and loss of canonical protein function. While neuronal
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Type 1 Diabetes (T1D), but a subset of individuals remains free from macrovascular or renal complications despite decades of hyperglycaemia and a significant risk factor burden. We used a targeted proteomic approach (Olink Cardiovascular panel III, targeting 92 proteins) to characterize the proteomic profile of cardiov
This thesis explores how an artist brand may move from commercial visibility toward cultural relevance and potential cultural iconicity within the contemporary music industry. While traditional brand management often focuses on market share, it often fails to explain how modern artists capture culture share. To address this gap, this study investigates how identity myths are utilized to address so
BACKGROUND: Previous research has shown that mobile health (mHealth) interventions are effective in reminding older adults with chronic conditions about health care appointments and promoting adherence to medication schedules. However, the evidence is limited by the short duration and poor quality of the interventions.OBJECTIVE: We evaluated the effectiveness of the Support, Monitoring and Reminde
Mot bakgrund av ett mer osäkert geopolitiskt omvärldsläge, ökad digitalisering och klimatrelaterade risker har frågor om energisystemens försörjningsberedskap fått ökad betydelse. Fjärrvärme utgör en samhällskritisk funktion av svensk energiförsörjning och spelar en central roll i klimatomställningen, samtidigt som systemen präglas av tekniska beroenden, komplexa leverantörskedjor och organisatori
Per- och polyfluorerade alkylsubstanser (PFAS) utgör en allvarlig global risk för dricksvatten på grund av sin persistens och höga mobilitet i vattenmiljöer. Vid Gorsingeholms vattenverk i Strängnäs uppvisade PFAS-koncentrationerna i råvattnet från Mälaren låga koncentrationer, men uppvisade förhöjda nivåer efter artificiell infiltration för grundvattenbildning (MAR). Eftersom infiltrationsmateria
BACKGROUND: Variants in the KCNQ1 underlie type 1 long QT syndrome. The clinical manifestations are influenced by the specific KCNQ1 pathogenic variant.OBJECTIVE: We aimed to describe the phenotype in patients found to possess the p.Gln530Ter-KCNQ1 pathogenic variant common in Scandinavian patients with long QT syndrome.METHODS: Clinical characteristics of p.Gln530Ter-KCNQ1 variant-positive patien
Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul
Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),
