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Hormone-sensitive lipase (HSL) and protein kinase B (PKB) are enzymes that in different ways are associated with lipid metabolism. While HSL is the well-known lipolytic enzyme responsible for hydrolysis of stored triacylglycerols in adipose tissue, PKB is a recently identified serine/threonine protein kinase, ubiquitously expressed and involved in signal transduction pathways induced by insulin an

Bone and soft tissue tumors (BSTT) constitute a heterogeneous group of neoplasms of mesenchymal and neuroectodermal origin. Although many BSTT are rare, it has become clear that BSTT are characterized by recurrent acquired chromosomal aberrations, and the general aim of this thesis have been to apply molecular genetic and molecular cytogenetic techniques to further characterize recurrent breakpoin

The thesis provides a discussion of the ecclesiology of the French Roman-Catholic theologian Henri de Lubac SJ (1896-1991) by showing how this is determined by his method of fundamental theology. I establish the term ?fundamental ecclesiology? for this inter-dependance of form and content, subject and object in theology; this is why his ecclesiology is sacramental in structure. I primarily use tex

Flexibility as well as constraints to the evolution of migration routes has the possibility of affecting large-scale patterns of geographical ranges of animals both by facilitating, but sometimes restricting, accessibility to and colonization of new regions. This dissertation concerns the broad-scale effects migration has on the distributional patterns of birds in the Arctic. I studied the circum

Malignant glioma is, with rare exceptions in younger adults, an uncurable brain tumor, as very few survive more than 1-2 years after diagnosis. Despite advances in recent years, current treatments such as surgery, radiotherapy and chemotherapy only prolongs the life of the patients. Because of the poor prognosis, several additional therapies have been investigated and are under development, such a

Multimodal transportation in the European continent is an integral part of cross border trade and in particular the use of sea and river carriers. The phenomenon of short sea shipping has reached a level of importance of which all European states must take cognisance. One of the policies associated with this issue is the development of the motorways of the sea. While Ukraine is not yet a part of t

I share my fascination of bird flight with many others, and here I summarise my thesis on the subject. This thesis emphasises the mechanics of bird flight by focusing on flight mechanics, wake dynamics and flight performance. Gliding flight performance of a jackdaw was measured in a wind tunnel and I conclude that the current model for predicting optimum wingspan as a function of forward gliding

Why is waste such an important topic for understanding the management of overflow? First, because waste is a classic symbol of overflow: to be flooded with too much stuff that demands handling, sorting, and decision-making is a feeling well known in consumer society. Facts and figures speak of the same overflow. Waste disposal is a growing problem. The downside of consumption is a growing mountain

Jobs and economic growth are created where businesses are located and investments made. A number of factors affect where firms choose to locate and where and how much that is invested. Many of these factors are hard to influence in the short run while others are governed by politicians and can be designed in order to stimulate desirable business and investment behaviour. One such factor is taxatio

Evacuation model capabilities are rapidly improving, allowing the simulation of ever more complex scenarios in different types of environments. The definition of the best evacuation modelling approach for safety assessment is a key point for optimizing engineering work and ensuring the desired safety conditions. In the present thesis, a wide comparison between modelling approaches has been provide

Aim Observations of long chronosequences in forest ecosystems show that, after some millennia of build-up, biomass declines in relation to the slow depletion of soil phosphorus. Plants that dominate during this period of soil impoverishment have specialized strategies for P acquisition, including ectomycorrhiza or root clusters. We use quantitative, pollen-based reconstructions of regional vegetat

In old mnemonic systems, like the Memory Palaces (Ricci) and the Memory Circles (Llull), the general purpose is to organize and preserve the images of memory over time. However, in contemporary discussions of memory taking place within the field of trauma studies (Leys, Laub, Feldman, Caruth, van der Kolk), the focus is on the forgotten, and on understanding why we do not remember traumatic events

Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious varian

Scand J Caring Sci; 2012 Satisfaction with rehabilitation in relation to self-perceived quality of life and function among patients with stroke - a 12 month follow-up Background and Purpose: Stroke causes complex disability and function, and perceived quality of life has been shown to correlate with satisfaction with care as well as with life in general among stroke patients. The aim of this study

We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a -blocker strategy or a calcium channel blocker strategy. Genom

The aim of this paper is to present an alternative method for the analysis of resistivity data. The methodology was developed during a study to evaluate if electrical resistivity can be used as a tool for analysing subsurface gas dynamics and gas emissions from landfills. The main assumption of this study was that variations in time of resistivity data correspond to variations in the relative amou

Parental type 2 diabetes mellitus increases the risk of diabetic nephropathy in offspring with type 1 diabetes mellitus. Several single nucleotide polymorphisms (SNPs) that predispose to type 2 diabetes mellitus have recently been identified. It is, however, not known whether such SNPs also confer susceptibility to diabetic nephropathy in patients with type 1 diabetes mellitus. We genotyped nine S

Next-generation sequencing technologies are making it possible to study the role of rare variants in human disease. Many studies balance statistical power with cost-effectiveness by (a) sampling from phenotypic extremes and (b) utilizing a two-stage design. Two-stage designs include a broad-based discovery phase and selection of a subset of potential causal genes/variants to be further examined in