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Background: Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19.

BackgroundGlobally, the COVID-19 pandemic had a huge impact on patients and healthcare systems. A decline in paediatric visits to healthcare settings was observed, which might have been due to lower incidence of injury and infectious illness, changes in healthcare services and parental concern. The aim of our study was to examine parental experiences of help-seeking for, and care of, a sick or inj

Aims/hypothesisPPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipocyte bi

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK variants. We aimed to investigate whether carriers of rare GCK variants diagnosed with T2D have a glycemic phenotype and treatment response consisten

While urbanization provides many opportunities to those arriving in thriving urban areas, a greater number of residents necessitates the expansion of housing and infrastructure. This is often achieved through densification, which can lead to increased noise, particularly through increased road traffic. A key challenge of promoting healthy urban planning is to understand potential health effects, e

Background: Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to specialist clinics. Internet-delivered BT has the potential of overcoming these barriers through remote delivery of treatment with minimal therapist

Objective: The aim was to compare rapid antigen detection test (RADT) and throat culture for group A streptococci (GAS) among patients recently treated with penicillin V for GAS pharyngotonsillitis. Design and setting: The study was a secondary analysis within a randomized controlled trial comparing 5 versus 10 days of penicillin V for GAS pharyngotonsillitis. Patients were recruited at 17 primary

Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the wider society. Especially since pain can start early in life and affect large parts of it. The aim of this thesis was to identify potential risk factors for chronic and

Background: Shoulder and arm dysfunction such as reduced range of motion (ROM) and seroma formation, are common complications following axillary lymph node dissection (ALND). There are conflicting results on the effect of early postoperative exercise on the risk of seroma. This study aims to present incidence of symptomatic seroma formation in a large, population-based cohort, and assesses whether

Aims/hypothesis: Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against GAD65 (GAD65Ab) on the incidence of adult-onset diabetes. Methods: We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onse

BackgroundOral treatment alternatives for febrile urinary tract infections are limited in the era of increasing antimicrobial resistance. We aim to evaluate if the combination of pivmecillinam and amoxicillin/clavulanic acid is non-inferior to current alternatives for step-down therapy in adult patients with febrile urinary tract infection.MethodsWe plan to perform an investigator-initiated non-in

The oxygen content of ancient seawater has been hypothesized to be a major controlling factor for biodiversity throughout Earth's history. The Great Ordovician Biodiversification Event (GOBE) represents one of the largest increases in biodiversity during the Phanerozoic, with peak rates of diversity occurring in the Middle–Late Ordovician. Multiple causal factors have resulted in this long-term ad

Given the recent predominant role of technology and the extensive use of smartphones in today’s society, the mobile device has become a major part of consumers’ daily lives. As a result, the lines between humans and technology have become blurred, where the effectiveness of interpersonal interactions at the service encounter in retail stores has been questioned. The researchers thus identified a k

To be able to cover future needs, in regards to urbanization and an increasing population, the construction industry must to a greater extent meet demands. One way to increase the production rate is by increasing the level of prefabrication and industrial building. If the industry had become better at learning from past mistakes, it would have given a greater opportunity to streamline processes, m

Purpose – The purpose of this thesis is to investigate the impact of gender neutral communication on brand image. Methodology – This study was conducted using the experimental design framework of pre- post random group. The respondents were assigned into two groups: control and intervention. In the control group the respondents were shown a gender stereotyped advertising and the intervention grou

The aim of this literature study was to answer whether the thermal impact of geothermal energy systems pose a potential environmental risk to groundwater quality and microorganisms in the sub surface and to above ground vegetation. This study shows that the thermal impact of high temperature systems operating with temperatures ≥25⁰C in groundwater could lead to adverse effects on groundwater chemi