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Platelet Indices and Risk of Death and Cardiovascular Events : Results from a Large Population-Based Cohort Study
Studies evaluating the relationship between platelet indices and cardiovascular (CV) outcomes yielded conflicting results. We assessed the incidence of adverse events according to baseline quintiles of platelet indices in the prospective cohort of the Malmö Diet and Cancer Study. A total of 30,314 individuals (age 57 ± 8 years) were followed for a median of 16 years (468,490 person-years). Outcome
Making more of middles: advancing the middle-out perspective in energy system transformation
Social and technological innovations are commonly seen as either being induced from the ‘top-down’ – e.g., by policymakers – or evolving from the ‘bottom-up’ – e.g., by consumers. Instead, a ‘middle-out’ perspective (MOP) focuses on agents of change that are located in the middle, between the top and the bottom. Janda and Parag (2013) and Parag & Janda (2014) describe how middle actors include
Robot-assisted approach to cervical cancer (RACC) : An international multi-center, open-label randomized controlled trial
Background Radical hysterectomy with pelvic lymphadenectomy represents the standard treatment for early-stage cervical cancer. Results from a recent randomized controlled trial demonstrate that minimally invasive surgery is inferior to laparotomy with regards to disease-free and overall survival. Primary Objective To investigate the oncologic safety of robot-assisted surgery for early-stage cervic
Physical inactivity increases the risk of endometrial cancer and premenopausal breast cancer
Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purp
Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period
BACKGROUND: The prevalence of multimorbidity is increasing worldwide, and older people with multimorbidity are frequent users of health care services. Since multimorbidity has a significant negative impact on Health-related Quality of Life (HrQoL) and is more common in older age it would be expected that factors related to HrQoL in this group might have been thoroughly researched, but this is not
Health-related quality of life and glycaemic control among adults with type 1 and type 2 diabetes - A nationwide cross-sectional study
Background: Health-related quality of life and glycaemic control are some of the central outcomes in clinical diabetes care and research. The purpose of this study was to describe the health-related quality of life and assess its association with glycaemic control in adults with type 1 and type 2 diabetes in a nationwide setting. Methods: In this cross-sectional survey, people with type 1 (n = 247
Mental health provision in schools: priority, facilitators and barriers in 10 European countries
Background: Although schools are a key setting for the provision of mental health support for young people, little is known about the facilitators and barriers for providing such support. This study aimed to collect information from schools in 10 European countries regarding the priority given to mental health support for students, existence of a mental health‐related school policy, links with rel
Maternal age and risk of cesarean section in women with induced labor at term—A Nordic register-based study
Introduction: Over the last decades, induction of labor has increased in many countries along with increasing maternal age. We assessed the effects of maternal age and labor induction on cesarean section at term among nulliparous and multiparous women without previous cesarean section. Material and methods: We performed a retrospective national registry-based study from Denmark, Finland, Iceland,
Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related
Carbon use efficiency of mycorrhizal fungal mycelium increases during the growing season but decreases with forest age across a Pinus sylvestris chronosequence
In boreal forest soils, mycelium of mycorrhizal fungi is pivotal for regulating soil carbon (C) cycling and storage. The carbon use efficiency (CUE), a key parameter in C cycling models, can inform on the partitioning of C between microbial biomass, and potential soil storage, and respiration. Here, we test the dependency of mycorrhizal mycelial CUE on stand age and seasonality in managed boreal f
Secondary Acute Myeloid Leukemia and the Role of Allogeneic Stem Cell Transplantation in a Population-Based Setting
Secondary AML (s-AML), including AML with an antecedent hematologic disorder (AHD-AML) and therapy-related AML (t-AML), constitutes a large proportion of patients with AML and is considered to confer a dismal prognosis. The role of allogeneic hematopoietic cell transplantation (HCT) in patients with s-AML and the extent to which HCT is performed in these patients has been little studied to date. W
Diagnostic Stability of Mild Cognitive Impairment, and Predictors of Reversion to Normal Cognitive Functioning
Objective: Studies that investigate predictive factors for spontaneous recovery (reversion) from mild cognitive impairment (MCI) are only beginning to emerge, and the long-term course of MCI is not properly understood. We aimed to investigate stability of the MCI diagnosis, predictors for reversion, as well as the trajectory of MCI over the course of 12 years. Materials and Methods: Data were draw
Grasslands ancient and modern : Soil nutrients, habitat age and their relation to Ellenberg N
Questions: To what extent does the long-term process of grassland succession reflect changes in nutrient availability or other effects of grassland history? Plant communities in ancient, semi-natural pastures include many species associated with nutrient-poor soils. However, semi-natural pasture communities can also develop on previously arable sites — as nutrient levels decline over time. In Euro
Clinical characteristics of the BREATHE cohort–a real-life study on patients with asthma and COPD
Wild bees and hoverflies respond differently to urbanisation, human population density and urban form
While urbanisation contributes to global biodiversity declines, flower-rich urban habitats may provide beneficial pollinator habitats. We investigated the potential of urban residential areas to contribute to pollinator diversity by analysing wild bee and hoverfly species richness and composition of species assemblages of summer-active species, sampled in 53 gardens across urban and rural landscap
Strategies to increase the rate of vaginal deliveries after cesarean without negative impact on outcomes
Children with palliative care needs - the landscape of the nordic countries
BACKGROUND: To strengthen palliative care for children in the Nordic countries, an updated status of current needs, resources, clinical services, education, and research is necessary to align and consolidate future research. A Nordic research collaboration initiative for children with palliative care needs was assembled in 2023. Building on this initiative, this paper presents an overview of pedia
Antihistamine use and osteoarthritis or joint pain
Generative AI in Higher Education : Educators' Perspectives on Academic Learning and Integrity
Generative Artificial Intelligence (Gen AI), exemplified by models such as ChatGPT, has rapidly advanced, becoming a significant force in various sectors, including higher education. ChatGPT, a leading application of Gen AI, utilizes large language models (LLMs) to generate human-like text, providing capabilities that range from answering complex questions to facilitating software development. As