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Background & Aims: Individuals with inflammatory bowel disease (IBD) are at increased risk of serious infections, but whether this risk varies by histologic disease activity is unclear. Methods: This was a national population-based study of 55,626 individuals diagnosed with IBD in 1990 to 2016 with longitudinal data on ileocolorectal biopsy specimens followed up through 2016. Serious infection

BACKGROUND: European guidelines recommend the use of a 0h/1h hs-cTn (high-sensitivity cardiac troponin) protocol in patients with acute chest pain. We aimed to determine the performance of this protocol in routine care when supplemented with patient history and ECG and a recommendation to refrain from noninvasive testing in low-risk patients.METHODS AND RESULTS: This was a pre- and postimplementat

Generative Artificial Intelligence (Gen AI), exemplified by models such as ChatGPT, has rapidly advanced, becoming a significant force in various sectors, including higher education. ChatGPT, a leading application of Gen AI, utilizes large language models (LLMs) to generate human-like text, providing capabilities that range from answering complex questions to facilitating software development. As

Background Self-harm is a prevalent health concern among youths, with significant psychosocial impacts on both youths and their parents. The aim of this study is to describe the impact of offspring self-harm on parental work absence. Methods This cohort study included 176 472 mothers and 161833 fathers of 17 726 youths with a first self-harm diagnosis between the years of 2006 and 2016 and 177 260

Today many of us strive to live as climate-friendly lives as possible, we stay informed with the ways that we can contribute and then try to alter our everyday habits accordingly. We often have an idea of what the best choice of transportation would be or that we should reduce our consumption in order to decrease our personal carbon footprint. Even with the best intentions our everyday-related dec

It is predicted that continentality, a climate parameter representative of a region’s annual temperature and precipitation range, will undergo significant changes in the future. The lack of past continentality reconstructions makes it impossible to decipher any long-term patterns of continentality changes. Here, we investigate the extent to which continentality influences modern chironomid assembl

Background: Despite considerable interest in the consequences of benzodiazepine and benzodiazepine-related Z-drug (BZDR) use, little is known about whether and how initiation of BZDR treatment relates to the development of alcohol- and drug-related problems. Aims: This study aimed to examine the association of incident BZDR dispensing with subsequent alcohol- and drug-related problems. Methods: Th

Background and aims: Animal studies have suggested that high salt intake might increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but results from populations are mixed, in part due to inadequate salt intake measurement. Salty taste preference is the primary factor leading to salt choice and can reflect habitual salt intake. However, no study has investigated

Background: Pain in children is undertreated. An assessment scale co-designed with children, parents, and health care professionals could lead to more effective pain assessments and treatment strategies aimed at reducing pain and pain-related symptoms. There are analogue scales validated for self-report of pain in children, but today, children regularly use digital technology, which healthcare sho

Chan HM, Jain R, Ahren B, Pacini G, D'Argenio DZ. Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice. Am J Physiol Regul Integr Comp Physiol 300: R1126-R1133, 2011. First published February 9, 2010; doi:10.1152/ajpregu.00687.2010.-The increase in insulin secretion caused by glucagon-like peptide-1 (GLP-1) and GLP-1 m

Background Previous research has established that direct and indirect forms of aggression differ in their association with gender and type of psychological difficulties. One purpose of the present study was to test if the same applies to direct and indirect victimization. A second purpose was to study these associations not only cross-sectionally (as in most previous research) but also longitudina

OBJECTIVES: Genomewide association studies (GWAS) have identified consistent associations with obesity, with a number of studies implicating eating behavior as a primary mechanism. Few studies have replicated genetic associations with dietary intake. This study evaluates the association between obesity susceptibility loci and dietary intake. METHODS: Data were obtained as part of the Diabetes Prev

There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop a methylation risk score (MRS) predicting CKD in individuals with newly diagnosed T2D. DNA methylation was analyzed epigenome wide in blood from 487 individuals