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AIMS: Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β-cell physiology, and their gene expression is reduced in T2D β cells. We investigate if loss of MAFA and MAFB in human β cells contributes to T2D progression by regul

This study focuses on the psycholinguistic problems that people may encounter when it comes to ambiguity. The most common words in English are ambiguous. An example is deck, which can both mean the deck of a ship or a deck of cards. To be able to distinguish the meaning of an ambiguous word, people naturally look at the context in which the word appears. So a sentence like ?The farmer filled the

The main purpose of the Thesis work is to conduct an assessment of both the way companies currently account for their waste costs, and of the potential relevancy of engaging in a more comprehensive cost accounting for waste in terms of achieving industrial waste minimisation and cost optimisation. In order to do so, literature about environmental and cost accounting was reviewed, an empirical stud

Electrical and electronic equipment (EEE) causes serious environmental impact in its end-of-life phase and it is the largest known source of heavy metals and organic pollutants in municipal waste. Moreover, waste electrical and electronic equipment (WEEE) containes valuable components that if recycled and reused, could reduce the use of virgin materials. However, nowdays WEEE is mostly landfilled.

Sammanfattning Jag har valt att problematisera varför vissa grupper och aktörer inte vill kalla sig för feminister och istället säger att de är för jämställdhet. Jag påstår därmed att på grund av det avståndstagandet har antifeminismen vuxit fram. Ordet feminist kopplas ofta samman med en vänsterpolitik, därför har jag valt att belysa högerns åsikter angående feminismen och jämställdhetsbegreppe

The aim of this essay is to make clear, whether or not, textile research is visualised in a wider archaeological discussion today. The aim is then to discuss what the archaeological and textile technological research situation in Scandinavia looks like today, and how that relate to what has happened in these two research fields during the years. This essay also has a purpose to find out if there i

BACKGROUND: Extensive exposure to per-and polyfluoroalkyl substances (PFAS) have been observed in many countries. Current deterministic frame-works for risk assessment lack the ability to predict the likelihood of effects and to assess uncertainty. When exposure exceeds tolerable intake levels, these shortcomings hamper risk management and communication. OBJECTIVE: The integrated probabilistic ris

Background: Data regarding the impact of preheart failure (HF) comorbidities on the prognosis of HF are scarce, especially in the younger HF patients. Objectives: To investigate pre-existing comorbidities in HF patients versus matched controls and to assess their impact on mortality. Methods: We included all first-time in-hospital and outpatient diagnoses of HF from 1995 to 2017, and comorbidities

Purpose: Personalized cancer treatment requires predictive biomarkers, including image-based biomarkers. Breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT) are in a clinically vulnerable situation with the tumor present. This study investigated whether mammographic density (MD), assessed pre-NACT, is predictive of pathological complete response (pCR). Methods: A total of 495 BC

Breast cancer is the most common type of cancer worldwide and the incidence is increasing. Women in low- and middle-income countries have a high mortality to incidence ratio mainly due to a lack of resources and organized health-care. A cheap and reliable breast diagnostic tool could enable an earlier diagnosis for low-resource countries and contribute to a reduction in breast cancer mortality. We

Musical meaning is multifaceted: both highly sensory and yet often abstract, able to cross cultural boundaries and yet embedded in specific traditions. For the most part it is not denotational (Monelle, 1991). Nevertheless, in “programmatic music”, musical themes are intended to refer to worldly objects and events on the basis of iconic (and indexical) grounds. Such non-arbitrariness of the sound-

Den 1 april 2019 kommer en ny djurskyddslag träda i kraft. En av de stora och viktiga ändringar för djurskyddet är att ett kunskapskrav ska införas i lagen. Ambitionen var att även ett utbildningskrav skulle införas i lagen men det visade sig vara oproportionerligt och alldeles för betungande för de enskilda. Ett problem som brukar förekomma vid ikraftträdande av en ny lag är att de nya bestämme

Framställningen undersöker två motstående intressen, behovet av välfungerande ansvarsregler för företag och det begränsade ansvaret för aktieägare i aktiebolag. Syftet med framställningen är att framställa principen om aktieägares frihet från personligt ansvar i ett brett perspektiv. Perspektivet breddas genom att undersöka tre begrepp som innebär att moderbolag kan åläggas ansvar för vad som geneThis essay examines two opposing interests: the need of well-functioning rules of liability and the limited liability for shareholders in companies. The purpose of this essay is to portray the principle of shareholders’ limited liability in a broad perspective. The essay widens the scope by examining three concepts that declares that parent companies can be responsible for what is generally the su