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This thesis aims to advance our understanding of how directors’ values influence board decision-making and firm behavior by developing and testing a model that integrates insights from behavioral perspectives on boards of directors and corporate governance. Ideally, boards engage in intensive and open discussions that utilize the full cognitive capacity of their members. However, in practice, they
BACKGROUND: Our aim was to explore the reasoning and experiences of women when offered a self-sampling HPV test.METHODS: This study implemented a qualitative study design and content analysis using an inductive approach. Data consisted of written narratives collected through open-ended questions from a total of 173 women. Women were included if they had been offered a self-sampling device since Se
Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma
BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M
Aims: Fetal insulin is a key regulator of fetal growth and the major contributor to high birth weight in pregnancies with maternal diabetes. There is evidence for genetic variation in regulating fetal insulin, but this has not been studied on a large-scale. We performed a genome-wide association study (GWAS) of umbilical cord insulin and c-peptide measurements to identify genetic variants associat
Introduction: Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well-being. Drawing on Self-Determination Theory (SDT), this study explores how adolescents make sense of hate speech and how these experiences affect autonomy, competence
Dissolved organic carbon (DOC) plays an essential role in the biogeochemistry and ecology of surface waters by influencing carbon cycle and microbial respiration. DOC is related to CO2 emissions from inland waters that can be compared to emissions of peatlands and DOC decay is influenced by environmental factors. Traditional methods used to measure DOC decay do not account for environmental factor
BACKGROUND AND OBJECTIVES: – The prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clin
Stormfloder betraktas som ett stort hot mot ekosystem och infrastruktur längs kuster, och hotet ökar på grund av det nuvarande föränderliga klimatet, med alltmer frekventa översvämningshändelser, erosion och sedimentomlagring. I detta sammanhang blir insatser för att identifiera spår av stormfloder i geologiska arkiv allt viktigare för att förstå effekterna av sådana händelser på miljön. Denna stuStorm-surges are considered a major coastal threat to ecosystems and infrastructure in the current changing climate, with increasingly frequent flooding events, erosion and sediment redistribution. In this context, efforts to identify traces of storm-surges in the geological record are becoming increasingly important to understand the impacts of such events on the environment. This project investi
BackgroundCytoreductive surgery is central to the management of advanced ovarian cancer. As the extent of surgery varies widely, assessment of postoperative risk is challenging. The Karolinska Surgical Extent and Complexity Score (K-SECS) was developed to quantify surgical extent and has previously been associated with survival. This study evaluated whether K-SECS is also associated with major pos
Bygg- och anläggningssektorn står idag för en betydande del av Sveriges totala klimatpåverkan. En del av denna påverkan uppstår i samband med hantering av schaktmassor. Samtidigt ökar kraven för en mer hållbar framtid och en cirkulär ekonomi vilket medför att nya lösningar inom masshanteringen behöver hittas. Syftet med studien är att undersöka vilka hinder och möjligheter som finns för ökad åter
Uppsatsen undersöker hur DNA-bevisning bör värderas i mål om vapenbrott där försvaret gör gällande att den tilltalades DNA överförts till vapnet genom sekundär överföring, det vill säga via en mellanhand snarare än genom direkt beröring. Syftet är att konstruera logiskt riktiga argumentationsstrukturer med hjälp av bayesianska nätverk, samt att belysa den bayesianska metodens möjligheter och begräThis thesis examines how DNA evidence should be evaluated in cases concerning firearms offences where the defence contends that the defendant's DNA was transferred to the weapon through secondary transfer that is, via an intermediary rather than through direct contact. The aim is to construct logically sound argumentative structures using Bayesian networks, and to shed light on the possibiliti
Introduction: Assay discrepancy in factor VIII activity between the one-stage and the chromogenic assays has been described in approximately one third of patients with non-severe haemophilia A. Whether assay discrepancy may also occur in patients with haemophilia B remains unknown. Aim: This study compared the results from the one-stage and the chromogenic assays in patients with haemophilia B. Me
Background - Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results - We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2 g) using data from 120 286 unrelated individuals of
Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants.Methods: C3 was analyzed in plasma from 4368 nondiabetic subjects, 46 to 68 years old, from the Malmö Diet and Cancer Study. Incidence o
Heart failure (HF) is the end-stage of all heart disease and arguably constitutes the greatest unmet therapeutic need in cardiovascular medicine today. Classic epidemiological studies have established clinical risk factors for HF, but the cause remains poorly understood in many cases. Biochemical analyses of small case-control series and animal models have described a plethora of molecular charact
Introduction: In 2011, the St. Gallen Consensus Conference introduced the use of pathology to define the intrinsic breast cancer subtypes by application of immunohistochemical (IHC) surrogate markers ER, PR, HER2 and Ki67 with a specified Ki67 cutoff (>14%) for luminal B-like definition. Reports concerning impaired reproducibility of Ki67 estimation and threshold inconsistency led to the initiatio
BACKGROUND: Reduced forced expiratory volume (FEV(1)) and forced vital capacity (FVC) are risk factors for myocardial infarction (MI) and stroke. However, the relationship with incidence of heart failure (HF) is incompletely known. This population-based study explored whether reduced FEV(1) or FVC is associated with the incidence of hospitalisation for HF. METHODS: 20 998 men (mean age 43 years) w
Formulating and implementing a new strategy may be a challenging task, especially if it alters the way in which a company has operated and positioned itself before. This may be particularly true for companies within the forest industry, like manufacturers of paper packaging products, pursuing differentiated customer value and innovative solutions where, traditionally, success has been measured in
