Search results

Background: Type 2 diabetes (T2D) is a complex disease characterised by chronic hyperglycaemia. The effects of elevated glucose on global gene expression in combination with DNA methylation patterns have not yet been studied in human pancreatic islets. Our aim was to study the impact of 48 h exposure to high (19 mM) versus control (5.6 mM) glucose levels on glucose-stimulated insulin secretion, ge

Background: Whilst tall stature has been related to lower risk of vascular disease, it has been proposed as a risk factor for atrial fibrillation. Little is known about other anthropometric measures and their joint effects on risk of atrial fibrillation. Objectives: We aim to investigate associations and potential joint effects of height, weight, body surface area (BSA) and body mass index (BMI) w

Fires including flammable gases and/or liquids differ from typical residential fires where the fuel is mainly composed of solid combustibles. The traditional ISO 834 curve was established to represent the timetemperature curve for a fully developed fire. However for combustible gases the type of thermal exposure might be substantially different and therefore other curves have been developed such a

Willow (Salix spp.) trees are commonly used in short rotation coppices (SRC) to produce renewable energy. However, these plants are also known to emit high concentrations of biogenic volatile organic compounds (BVOCs), which have a large influence on air quality. Many different clones of commercially used Salix varieties exist today, but only a few studies have focused on BVOC emissions from these

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous efforts in three dimensions, examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional

In this longitudinal, prospective study, 39 preterm children, consecutively born before 35 weeks of completed gestation and 23 full-term children were followed up after 19 years. Multifaceted aspects of outcome were evaluated. The results indicate a clear increase in somatic morbidity during growth and young adulthood among the preterms. Psychometric evaluation of cognitive development at age 19 y

The purpose of the study was to characterise the phenotype with emphasis on electroretinography in four different types of hereditary retinal degeneration and to correlate it to a genotype when possible. Two methods were used: full-field electroretinography for objective assessment of retinal function and mutation screening of blood samples for detection of gene alterations. Electroretinograms fro

A paradigm shift is emerging in higher education especially regarding how universities should address personalized and collaborative mobile learning. Experiences from three international benchmarking-projects through the European Association of Distance teaching Universities (EADTU), the European Centre for Strategic Management of Universities (ESMU) and the First dual mode benchmarking club on qu

This doctoral thesis explored three broad aspects of preschoolers’ social competence: prosocial behavior, aggression, and social cognition. The longitudinal study followed forty-four children (initially 22-40 months), who were observed in natural peer interactions at their daycare centers during a two-month period in each of three con-secutive years. In addition, social-cognitive data were gathere

Secretory leukocyte protease inhibitor is a 11.7 kDa acid stable serine protease inhibitor. SLPI has been shown to be the dominant protease inhibitor in bronchial secretions and has been used in treatment of pulmonary emphysema. In ulcerative colitis faecal extracts has been shown to contain an abundance of free proteolytic activity, mainly leukocytic and pancreatic proteases. SLPI is a strong inh

Kan civila som blivit måltavla för krigshandlingar försonas med sina före detta fiender? Denna studie analyserar muntligt gestaltade erfarenheter hos före detta lägerfångar som frihetsberövades i början av kriget i Bosnien-Hercegovina under 1990-talet och placerades i koncentrationslägerna Omarska, Keraterm och Manjaca. Efter kriget har fångarna tagit sin tillflykt till de nordiska länderna. StuIs it possible for civilians, who have been targets of war action, to reconcile with their former enemies? In this study I am analyzing the stories told by former camp-prisoners who were imprisoned at the beginning of the Bosnia-Herzegovina war in the early 1990’s. These prisoners were detained in the concentration-camps of Omarska, Keraterm and Manjača. The former prisoners took refuge in the Nor

Synchrotron radiation laboratories are large scientific facilities where various scientific experiments are carried out by the use of radiation produced by particle accelerators. Research with synchrotron radiation emerged in the 1960s and 1970s as a peripheral activity at particle physics laboratories. It has since expanded and taken over facilities from particle physics, and developed specialize

The drafters of the 1990 Dublin Convention knowingly and willfully disregarded divergences among Member States' protection systems. Like a boomerang, the fallacy of this approach has now reappeared in cases where asylum seekers have challenged transfers under the Convention, tasking judges to tackle a problem which its drafters avoided. The core issue of this article is whether and when such diver