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Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and C-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female GIP recep
Aim Observations of long chronosequences in forest ecosystems show that, after some millennia of build-up, biomass declines in relation to the slow depletion of soil phosphorus. Plants that dominate during this period of soil impoverishment have specialized strategies for P acquisition, including ectomycorrhiza or root clusters. We use quantitative, pollen-based reconstructions of regional vegeta
Evacuation model capabilities are rapidly improving, allowing the simulation of ever more complex scenarios in different types of environments. The definition of the best evacuation modelling approach for safety assessment is a key point for optimizing engineering work and ensuring the desired safety conditions. In the present thesis, a wide comparison between modelling approaches has been provide
This dissertation studies the effects that the use of a word-processing program can have on pupils' writing. The study was conducted with a consideration of the context in which the writing was done. It examined not just changes in the quality of the pupils' writing but also the attitudes of pupils, teachers, and parents to computer-aided writing. In addition, it studied the functional reliability
Jobs and economic growth are created where businesses are located and investments made. A number of factors affect where firms choose to locate and where and how much that is invested. Many of these factors are hard to influence in the short run while others are governed by politicians and can be designed in order to stimulate desirable business and investment behaviour. One such factor is taxatio
In old mnemonic systems, like the Memory Palaces (Ricci) and the Memory Circles (Llull), the general purpose is to organize and preserve the images of memory over time. However, in contemporary discussions of memory taking place within the field of trauma studies (Leys, Laub, Feldman, Caruth, van der Kolk), the focus is on the forgotten, and on understanding why we do not remember traumatic events
Ectomycorrhizal fungi form symbiotic associations with tree roots and assist in nutrient-uptake and -cycling in forest ecosystems, thereby constituting a most significant part of the microbial community. The aims of the studies described in this thesis were to evaluate the potential of DNA-based molecular methods in below-ground ectomycorrhizal community studies and to investigate changes in ectom
Popular AbstractAvhandlingen presenterar, från ett fenomenologiskt perspektiv, interaktionen mellan naturvetenskapens kunskap och annan kunskap, här kallad "vardagskunskap". Utgångspunkten i presentationen är människans existens. Två aspekter av denna lyfts fram som centrala - att människan är kroppsligt utsatt för, berörd av, något hon inte har full kontroll över, samt att hon alltid agerar utifrThe dissertation presents a phenomenological view on the interaction between science knowledge and prescientific knowledge. Drawing on Husserl, Merleau-Ponty and Lévinas the human bodily grounded existence is described, the central feature of this existence being its responsivity to the Other. This responsivity is presented as the starting point for the production of science knowledge, thus making
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Its association with venous thromboembolism (VTE) has been inconsistently reported. We investigated the association between MetS and VTE, and the influence of sex and abdominal obesity. We included 12,788 middle-aged and older adults from the re-ex
Background: Insulin resistance and impaired insulin secretion are hallmarks of type 2 diabetes (T2D) and may influence risks of complications including dementia. We investigated dementia risk across T2D subgroups defined by beta-cell function and insulin sensitivity. Methods: We used Homeostasis Model Assessment-2 indices of beta-cell function (HOMA2-B) and insulin sensitivity (HOMA2-S) to classif
Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th
BackgroundAlzheimer’s disease (AD) is the most common cause of dementia and a growing healthcare challenge. Amyloid-targeting therapies (ATT) may slow progression, but implementation is limited by logistical and economic barriers. As primary care is the first contact for most patients with cognitive concerns, quantifying treatment eligibility in this setting is essential. The purpose of this study
Background: The incidence of pancreatic cancer (PC) and autoimmune diseases (ADs) has been increasing worldwide. While certain associations between specific ADs, such as pancreatitis, and PC have long been well confirmed, population-focused research investigating the broader spectrum of ADs and their relationship with PC risk remains limited. Methods: We implemented a cohort study based on populat
Background: This is one of the few European studies of self-management and self-monitoring during the initial two weeks following discharge after open cardiac surgery. Typical outcomes are mortality, morbidity, surgical complications and additional medical treatment. Equally important for enabling person-centred care are the patients’ perspective and main concerns. The aim was to explore feasibili
BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m
Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line
The evacuation of hospitals in the event of fires and similar emergencies can be a difficult endeavor. Patients usually require assistance, with a considerable number of them being unable to evacuate by themselves due to medical conditions or due to the treatment they are receiving. Assistance is to be provided by the healthcare staff in the affected ward, which means that their level of preparedn
