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BackgroundPatient education and dialogue are important when choosing a future treatment strategy for patients with chronic kidney disease. To support patients in their decision-making process, it is critical to provide information in a way that patients can understand. This study was conducted to understand how nephrologists view the goals of information sharing, the challenges involved, and the s
Context: The mechanisms underlying bone fragility and increased fracture risk observed in individuals with type 2 diabetes (T2D) are not yet fully elucidated. Previous research has suggested a role for neuropeptides in regulating bone metabolism; however, the contribution of the neuropeptide Neurotensin (NT), which is thoroughly implicated in T2D and cardiovascular disease, has not been investigat
Background: The incorporation of artificial intelligence (AI) into point-of-care ultrasound (POCUS) platforms has rapidly increased. The number of B-lines present on lung ultrasound (LUS) serve as a useful tool for the assessment of pulmonary congestion. Interpretation, however, requires experience and therefore AI automation has been pursued. This study aimed to test the agreement between the AI
BackgroundImpulsive-compulsive disorders (ICDs) are commonly acknowledged as side effects of dopaminergic therapy in Parkinson’s disease (PD). While many large-scale studies have focused on prevalences and high-risk treatments, little is known about practical management of ICDs in clinical care and patients’ experiences.ObjectiveTo investigate how ICDs are recognized in clinical PD care, clinical
Background and objective The Scania Accelerated Intermittent Theta-burst Implementation Study (SATIS) aimed to investigate the tolerability, preliminary effectiveness, and practical feasibility of an accelerated intermittent theta burst stimulation (aTBS) protocol in treating depression. Methods We used an open-label observational design, recruiting 20 patients (aged 19–84 years) from two public b
Aims: TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials and Methods: We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabete
Aim: Accumulated data suggest that routine use of defunctioning stoma in low anterior resection for rectal cancer may cause kidney injury, bowel dysfunction and a higher risk of permanent stomas. We aim to study whether avoidance of a diverting stoma in selected patients is safe and reduces adverse consequences. Methods: SELSA is a multicentre international prospective observational study nesting
Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe
IntroductionNon-beta-haemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with HVP and non-beta-haemolytic streptococcal bacteraemia (NBHSB), and to study NBHSB relapse depending on treatment duration.MethodAdults with HVP and NBHSB 20
Atrial fibrillation (AF) is common condition among the elderly, and leads toincreased risks of stroke, heart failure, dementia, and death. Diagnosing AF requires electrocardiograms (ECGs), and long recordings may be necessary since AF often occurs intermittently in its early stages. During AF, the heart rate is irregular, and sometimes inappropriately fast. This thesis includes four papers that st
Background and aim: Telomere length (TL) is a key biomarker of cellular aging, with shorter telomeres associated with age-related diseases. Lifestyle interventions mitigating telomere shortening are essential for preventing such conditions. This study aimed to examine the effects of two weight loss dietary strategies, based on a moderately high-protein (MHP) diet and a low-fat (LF) diet on TL in i
Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an
