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HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our analysis uncovered (αa1, α44, α157, α196) and (β9, β30, β57, β70, β135) on the HLA-DQ molecule. The

Contemporary society is confronted with numerous sustainability challenges. Some are new, others have been around since time immemorial, but none have been governed on the societal level since their emergence. Despite an abundant literature that addresses the governing of a range of such sustainability challenges, the processes through which they become something governable in the first place have

BACKGROUND: Few studies have assessed the mental health of principals, or studied associations with both organizational and social work environment factors and occupational balance. The purpose of the present study was therefore to investigate associations between supporting and demanding organizational and social work environment factors, occupational balance and stress symptoms in principals.MET

In Sweden, austerity politics and market reforms have resulted in a renegotiation of working conditions negatively impacting female-dominated public sector- and welfare state workers. A growing body of research locates the harshening conditions of nurses in a context of colliding logics between professions and professional authority, the specificities of interpersonal work, and public sector restr

Organic carbon burial in lake sediments plays an important role in the global carbon cycle, and is heavily affected by the terrestrial organic matter input. However, few studies have focused on long-term changes in terrestrial organic matter input to lakes in response to land-use changes. The aim of this study was to assess variations in sedimentary terrestrial organic matter over the last 1000 ye

INTRODUCTION: Complement-mediated atypical hemolytic uremic syndrome (aHUS) is an ultra-rare renal disease primarily caused by genetic alterations in complement proteins. The genetic work-up required for confirmation of diagnosis is complicated and not always logistically accessible. The aim of the present study was to apply a diagnostic scheme compliant with the ACMG guidelines to investigate the

The aim of this paper is to analyse the type of mobilities and subjects that are being promoted and constituted through bike-sharing systems. This is done through an analysis of the bike-sharing system in the city of Lund in Sweden. The analysis utilises Bacchi’s What is the Problem Represented to be? framework and develops it through adding a spatial perspective. Departing from a critical velomob