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The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina
Adaptive reuse, the conversion of buildings for new functions, is gaining prominence for its cost-saving and environmental benefits. However, prior research primarily focuses on preserving the building envelope, often overlooking building services such as ventilation, which affect occupant well-being, costs, and environmental performance. This study explores a novel adaptive reuse approach by reus
Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence
Science is a risky business, and risk-taking is a critical disposition for scientists. This study uses a combination of survey and bibliometric data to measure the degree of individual scientists' risk-taking and investigate its determinants. In particular, we focus on academic training as a critical arena for the socialization of risk-taking and examine whether and how risk-taking is transmitted
This study assesses the feasibility of extracting high-quality DNA from blood samples stored at – 20 °C for up to 21 years under suboptimal conditions. It addresses sample mishandling in research, where many samples lack proper biobank protocols. Prior studies focused on short-term storage and controlled conditions, highlighting the negative effects of freeze–thaw cycles. This study evaluates whet
In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective
The major histocompatibility complex (MHC) plays a key role in pathogen recognition as part of the adaptive immune system. MHC I gene copy numbers in birds of the order Passeriformes (songbirds) are substantially larger compared to other birds. MHC I diversity and antigen presentation have been carefully characterised in chicken Gallus gallus of the order Galliformes; chickens express few MHC I ge
Introduction: Fatigue is a troublesome symptom after heart transplantation and is poorly studied in a long-term perspective. One hypothesis is that there is a strong relationship between fatigue, sleep problems, and self-efficacy, and that fatigue decreases self-efficacy. The aim of this study was to explore self-reported fatigue from the time on the waiting list to 5 years after heart transplanta
Based on a combination of morphometric analyses, a chloroplast DNA phylogeny, and multivariate analyses of whole genome sequence data from >300 museum samples, we discuss and evaluate the delimitation, taxonomy, and evolution of wild and escaped taxa in Mentha subgen. Mentha, focusing on the northern hemisphere. Thirteen species (Mentha aquatica, M. arvensis, M. australis, M. capensis, M. dahurica
Climate change (CC) is altering the working conditions for water suppliers. To enhance preparedness, CC has been emphasised in the risk-based approach (RBA) and water safety planning guidelines. We studied how the RBA approach has been applied in small water supplies in the Nordic countries to mitigate CC related risks and impacts. We interviewed small water supply operators and authorities in eac
Vaccine hesitancy and anti-vaccination attitudes are becoming increasingly problematic in several Western countries where diseases that were nearly extinct are coming back. We here explore the role of perceived social support in understanding anti-vaccination attitudes. We argue that perceptions about having social support for one′s position may influence anti-vaccination attitudes among some soci
Background: The occupational therapy intervention, Active in My Home (AiMH), puts occupational engagement, participation in society and personal recovery in focus and includes increased staff support. Aims/Objectives: To investigate how the residents experienced the AiMH support, with a focus on their possibilities for engaging in occupations and participating in society after the intervention. Ma
Smoking is widely regarded as a risk factor for type 2 diabetes because nicotine contributes to insulin resistance by desensitizing the insulin receptors in muscle, liver, or fat. Little is known, however, about the immediate regulation of islet hormonal output by nicotine, an agonist of ionotropic cholinergic receptors. We investigated this by imaging cytosolic Ca2+ dynamics in mouse and human is
In recent years, there has been an increasingly larger fraction of intermittent energy sources. In the northern parts of Europe, the main source of intermittent power is wind power. This source of power is low inertia, inconsistent and will always fluctuate with different magnitudes, leaving a need for balancing. One source of balancing is to have the widespread non-zero inertia combined heat and
Individuals born with low birth weight are at increased risk of type 2 diabetes, which potentially may be attributed to immature adipose tissue development and reduced levels of the insulin-sensitizing adipokine, adiponectin. This systematic review and meta-analysis synthesize data from 67 studies, comprising over 8000 individuals across various age groups, to examine the relationship between circ
Body dysmorphic disorder (BDD) is frequently overlooked and untreated due to insufficient awareness and expertise in mental health settings. We developed a supervisor-supported online education programme to train clinicians in the assessment and treatment of young people with BDD and evaluated its feasibility and preliminary effects. Thirty clinicians working within child and adolescent mental hea
