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Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in the literature. In 1985, WHO formally classified it as malnutrition-related diabetes, but subsequently removed the classification in 1999 over a disagreement as to whether undernutrition was a suffici

Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube. This study unveils the pivotal role of Hamlet (Ham), a Drosophila PR domain containin

The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina

Adaptive reuse, the conversion of buildings for new functions, is gaining prominence for its cost-saving and environmental benefits. However, prior research primarily focuses on preserving the building envelope, often overlooking building services such as ventilation, which affect occupant well-being, costs, and environmental performance. This study explores a novel adaptive reuse approach by reus

Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence

Science is a risky business, and risk-taking is a critical disposition for scientists. This study uses a combination of survey and bibliometric data to measure the degree of individual scientists' risk-taking and investigate its determinants. In particular, we focus on academic training as a critical arena for the socialization of risk-taking and examine whether and how risk-taking is transmitted

This study assesses the feasibility of extracting high-quality DNA from blood samples stored at – 20 °C for up to 21 years under suboptimal conditions. It addresses sample mishandling in research, where many samples lack proper biobank protocols. Prior studies focused on short-term storage and controlled conditions, highlighting the negative effects of freeze–thaw cycles. This study evaluates whet

In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

The major histocompatibility complex (MHC) plays a key role in pathogen recognition as part of the adaptive immune system. MHC I gene copy numbers in birds of the order Passeriformes (songbirds) are substantially larger compared to other birds. MHC I diversity and antigen presentation have been carefully characterised in chicken Gallus gallus of the order Galliformes; chickens express few MHC I ge

Introduction: Fatigue is a troublesome symptom after heart transplantation and is poorly studied in a long-term perspective. One hypothesis is that there is a strong relationship between fatigue, sleep problems, and self-efficacy, and that fatigue decreases self-efficacy. The aim of this study was to explore self-reported fatigue from the time on the waiting list to 5 years after heart transplanta

Based on a combination of morphometric analyses, a chloroplast DNA phylogeny, and multivariate analyses of whole genome sequence data from >300 museum samples, we discuss and evaluate the delimitation, taxonomy, and evolution of wild and escaped taxa in Mentha subgen. Mentha, focusing on the northern hemisphere. Thirteen species (Mentha aquatica, M. arvensis, M. australis, M. capensis, M. dahurica

Climate change (CC) is altering the working conditions for water suppliers. To enhance preparedness, CC has been emphasised in the risk-based approach (RBA) and water safety planning guidelines. We studied how the RBA approach has been applied in small water supplies in the Nordic countries to mitigate CC related risks and impacts. We interviewed small water supply operators and authorities in eac

Vaccine hesitancy and anti-vaccination attitudes are becoming increasingly problematic in several Western countries where diseases that were nearly extinct are coming back. We here explore the role of perceived social support in understanding anti-vaccination attitudes. We argue that perceptions about having social support for one′s position may influence anti-vaccination attitudes among some soci

Background: The occupational therapy intervention, Active in My Home (AiMH), puts occupational engagement, participation in society and personal recovery in focus and includes increased staff support. Aims/Objectives: To investigate how the residents experienced the AiMH support, with a focus on their possibilities for engaging in occupations and participating in society after the intervention. Ma

Smoking is widely regarded as a risk factor for type 2 diabetes because nicotine contributes to insulin resistance by desensitizing the insulin receptors in muscle, liver, or fat. Little is known, however, about the immediate regulation of islet hormonal output by nicotine, an agonist of ionotropic cholinergic receptors. We investigated this by imaging cytosolic Ca2+ dynamics in mouse and human is