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During the last decade, a rapid progress has been made in the development of validated analytical models for the thermal and mechanica1 behaviour of fire exposed structures and structural members. In a long-term perspective, the development now goes towards an analytical design, directly based on a natural fire exposure and specified with respect to the combustion characteristics of the fire load

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BACKGROUND AND PURPOSE: Genome-wide association (GWA) studies have identified a few risk loci for ischaemic stroke, but these variants explain only a small part of the genetic contribution to the disease. Coding variants associated with amino acid substitutions or premature termination of protein synthesis could have a large effect on disease risk. We performed an exome array analysis for ischaemi