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Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPK alpha 1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPK alpha 1(-/-) mice. In vivo loss-of-function (LysM-

Type 2 diabetes is triggered by reduced insulin production, caused by genetic and environmental factors such as inflammation originating from the innate immune system. Complement proteins are a component of innate immunity and kill non-self cells by perforating the plasma membrane, a reaction prevented by CD59. Human pancreatic islets express CD59 at very high levels. CD59 is primarily known as a

Secretion from many endocrine cells is a result of calcium-regulated exocytosis due to Ca(2+) influx. Using the patch-clamp technique, voltage pulses can be applied to the cells to open Ca(2+) channels, resulting in a measurable Ca(2+) current, and evoke exocytosis, which can be seen as an increase in membrane capacitance. A common tool for evaluating the relation between Ca(2+) influx and exocyto

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that f

In foster care research the focus is generally placed on the children, not on the parents who perform the foster care. In this article the focus is on foster parents of 10-11 year-old children. They were interviewed about their motives for becoming foster parents, which were linked to their family and work circumstances. Among the 21 foster families in the study, four different but equally frequen

A denuder/filter system constructed for solvent-free personal exposure measurements was evaluated for separation of vapour and particulate 4,4'-methylenediphenyl diisocyanate (4,4'-MDI) generated from heated PUR-foam. The two different phases were collected in the denuder and on the filter, respectively, by chemosorption on a polydimethylsiloxane (SE-30)-dibutylamine (DBA) stationary phase. Both r

The emotional aspects of the care-giving relationship in home-care services are studied, starting from the home-care recipients' and the home-care workers' perception of the emotional climate. Their experiences of the care-giving relationship and the influence from different aspects of the care-giving situation and social processes in the work organisation are explored. Two hundred and twenty-two

The effect of using different binding agents in combination with hemp shives and fibres in Lime-Hemp Concrete (LHC) building material was examined. LHC is a light composite building material with building lime as binding agents and hemp (Cannabis sativa) as a renewable raw material from agriculture. Contemporary LHC only uses the woody core part of the hemp, the shive. However, using both hemp shi

This article addresses the predominant degradation modes and life prediction of a plasma-sprayed thermal barrier coating (TBC). The studied TBC system consists of an air-plasm a-sprayed bond coat and an air-plasma-sprayed, yttria partially stabilized zirconia top layer on a conventional Hastelloy X substrate. Thermal shock tests of air-sprayed TBC and pre-oxidized TBC specimens were conducted unde

OBJECTIVE: The primary aim was to explore patients' knowledge of heart failure and their attitudes toward medical information (prognostic information in particular) and to assess different patient-related factors that might hamper the improvement of patients' knowledge. Moreover, taking the data obtained into account, we analyzed ethical aspects of information disclosure to patients with heart fai

In this paper, we present and discuss results from an investigation of verb placement in modern Faroese in which we collected data from speakers from a number of different dialect areas in the Faroe Islands. Altogether we interviewed 54 informants (age 15 – 67, 29 women and 25 men). Therefore, our study not only investigates the geographical variation claimed to be present in Faroese with respect