Today, more than half of the world’s population live in cities, and by mid-century it is predicted that more than two-thirds of the world’s population will live in urban areas. This sees cities at the forefront of sustainability, needing to meet social needs within our ecological boundaries. An overarching guiding roadmap to consider sustainability is the United Nations’ Sustainable Development Go

Background The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (PROCR) was associated with venous thromboembolism (VTE) in genome-wide association studies. Objectives This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older

Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of n

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used -1/4155,063 samples for independent replication. We identified 30 new bloo

Raw municipal wastewater from a full-scale wastewater treatment plant was physicochemically pretreated in a large pilot-scale system comprising coagulation, flocculation, microsieve and microfiltration operated in various configurations. The produced microsieve filtrates and microfiltration permeates were then concentrated using forward osmosis (FO). Aquaporin InsideTM FO membranes were used for b

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducible kinases (SIKs) control subcellular localization of HDAC4/5 and CRTC2. PTH regulates both HDAC4/5

Among the issues relating to the needs of citizens with reduced functional capacity, accessibility problems throughout society are gaining interest. The focus of this paper is on methodology for assessment of urban public bus transport accessibility. The aims are to describe the development of a pilot version of a new instrument, the Travel Chain Enabler, and to identify problems to target for fur

The seventeenth century saw the culmination of what has traditionally been called “Lutheran Orthodoxy”. Earlier a rather underestimated period, the time of “Lutheran Orthodoxy” has started to attract a fairer share of attention within the concept of Confessional Culture (recently coined by Professor Dr. Thomas Kaufmann). An enormously important but sometimes slightly overlooked part of this cultur

In most of the world, borehole heat exchangers used with closed-loop ground source heat pump systems are backfilled with a low permeability grout to prevent water contamination. However, in Scandinavian countries, a different approach is taken – the borehole is sealed at the top and cased down to solid bedrock. The borehole then naturally fills with groundwater in the annular space between the U-t

This paper adds to the relatively few European studies on the pedestrian friendliness of urban areas, and on transport walking. Using the Human Environment Interaction (HEI) model (Küller, 1991), the study explores the associations between perceived neighbourhood spatialphysical and social environment qualities and walking to neighbourhood destinations, and examines whether these associations are

This study introduces a corpus of 260 naturalistic human nonlinguistic vocalizations representing nine emotions: amusement, anger, disgust, effort, fear, joy, pain, pleasure, and sadness. The recognition accuracy in a rating task varied greatly per emotion, from 70% for amusement, pleasure, fear, and sadness. In contrast, the raters’ linguistic–cultural group had no effect on recognition accuracy:

Increasingly, scholars are examining the ways in which the Internet allows the hate movement to retrench and reinvent itself as a viable collective. The many electronic means available to the movement – blogs, newsgroups, ’zines, etc. – allow an ease of communication and dissemination of their views never before possible. While there are obvious points of convergence across the various Klan groups