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The discovery of the incretin hormone glucagon like peptide-1 (GLP-1), and its usefulness in the treatment of type 2 diabetes mellitus (T2DM) followed by the finding that dipeptidyl peptidase-4 (DPP-4) inhibition prevents GLP-1 inactivation, led to the discovery of DPP-728. In 1999, studies with DPP-728 established the first proof-of-concept that DPP-4 inhibition improves glycaemic control in pati

Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo

It is a trivial fact that water is needed for decay of wood by brown rot fungi, but when this is looked at in more detail, there are several fundamental questions concerning water and decay that are not solved. The purpose of this study is to study how the wood-water interaction is changed during degradation of brown-rot fungi of Norway spruce (Picea abies (L) Karst.) grown at two different parts

A film on identity & hydropolitics in the Israeli occupied Golan Heights. Majdal Shams is a Syrian village in the Golan Heights, a water rich plateau located between Israel and Syria. The Syrian citizens of Majdal Shams and four other villages have been under Israeli occupation since the October war in 1973. After 40 years their on-going resistance is in the form of refusing Israeli citizenshi

The issue of the pro’s and coins with representatives from different interest group on corporate board is lively discussed. Will representatives from stakeholders work in the interest of the stake they represent or in the interest of the companies where they are a director? The issue has a renewed topicality as claim for e.g. consumer groups or experts on environmental issues have been raised. In

A nonlinear least squares method for continuous measurement ofthe air flow in a 'dynamic insulation' was presented. The methodis called the gradient method to indicate that the temperature gradientsin the insulation are used. The method includes one dimensionaltransient and steady state calculations ofthe heat transfer inthe insulation. The model was verified by analytical and numericalsimulations

"Early Modern Text Recycing: On the Study of Neolatin Texts". The study of Neo-Latin texts is discussed with special regard to intertextuality. It is argued that intertextuality in Neo-Latin texts depends partly on the fact that Latin was learnt through imitation, partly on the existence of a rich variety of multifaceted texts - which cannot be classed as either "literary" or "non-literary" - with

Wetland creation at large, regional scales is implemented as a measure to abate the biodiversity loss in agricultural landscapes and the eutrophication of watersheds and coastal areas by non-point source nutrient pollution (mainly nitrogen). The consequences of creating many new wetlands for biodiversity conservation and nutrient retention (ecosystem functioning) in agricultural landscapes are sti

This thesis consists of four self-contained essays on different conflicts shaping local government policy. The first essay examines how population aging affects the generosity of public long-term care. Aging may directly affect long-term care policy as the elderly become a more important voter group. However, concerns for other citizens may dampen the political importance of the elderly. Fixed e