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Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL) and a principal mediator of the reverse cholesterol transfer pathway. Variants of apoA-I have been shown to be associated with hereditary amyloidosis. We previously characterized the G26R and L178H variants that both possess decreased stability and increased fibril formation propensity. Here we investigate the Milano
This article investigates the relation between conceptions of status and processes of militarization of peasants in the medieval and early-modern society. In an initial overview we see how many revolts in western Europe in late middle ages were connected to an increased military participation of peasant groups. After 1500 similar processes can be found in the east european frontier regions. Econom
In photonuclear experiments precise location of the photon beam relative to the experimental sample is critical. Previously used techniques such as using photographic film to identify the position, intensity and centroid of the beam is time-consuming and a faster method is required. PILATUS is a single-photon-counting pixel detector developed at the Paul Scherrer Institute (PSI), Switzerland. It i
The customary way to determine whether an adopted Supplemental Instruction (SI) program has been successful or not is by comparing course results for two groups, SI attendees and non-attendees. The division of SI attendees and non-attendees is generally done rather arbitrarily by prescribing a minimum number of SI sessions a student has to attend to be considered an SI attendee. Although the SI at
Business organizations may expand internationally by replicating a part of their value chain, such as a sales and marketing format, in other countries. However, little is known regarding how such "international replicators" build a format for replication, or how they can adjust it in order to adapt to local environments and under the impact of new learning. To illuminate these issues, we draw on a
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, e
Abstract in UndeterminedVegetated roofs are becoming increasingly popular in urban environments. Still, several aspects of their influence on various urban infrastructures are not sufficiently investigated, including the roofs' influence on runoff water quality. In this study a first flush effect in runoff water from vegetated roofs during simulated artificial rain events is investigated. Example
Genome sequencing can identify individuals in the general population who harbor rare coding variants in genes for Mendelian disorders1-7 and who may consequently have increased disease risk. Previous studies of rare variants in phenotypically extreme individuals display ascertainment bias and may demonstrate inflated effect-size estimates8-12. We sequenced seven genes for maturity-onset diabetes o
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an addit
The topics of regional innovation systems (RIS) and cross-border regions attract increasing attention, but few studies combine the themes. Further, the existing empirical studies of cross-border innovation and knowledge creation analyse one case at one point in time, thus, making it difficult to assess the progress of integration in the regions, as well as the effect of cross-border innovation pol
This paper reports on the results of a cross-sectional study that focused on the impact of attitudes, subjective norms and consumer innovativeness on intention to purchase cosmetic products. Beginning with the Theory of Reasoned Action (Ajzen & Fishbein, 1980; Fishbein, 1980; Fishbein & Ajzen, 1975), several models have been proposed to conceptualize the complex behavioral and social proce
Background Primary Sjogren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocrine pathways involving the muscarinic receptor 3 (CHRM3) has been indicated. Obje
Waste heat recovery systems for power generation are gaining interest among the marine transport sector as a solution to accomplish the upcoming more restrictive regulations on emissions, and to reduce the total fuel consumption. In this paper we evaluate how a waste heat recovery system based on a regenerative organic Rankine cycle (rORC) could improve the performance of a passenger vessel. The c
The spruce seed moth, Cydia strobilella L., is a serious pest on cones of spruce (Picea spp.) in the Holarctic region. Previous studies from different parts of its area of distribution have reported conflicting results on the composition of its sex pheromone. By gas chromatography with electroantennographic detection, coupled gas chromatography-mass spectrometry, a Y-tube olfactometer bioassay, an
