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The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular s

Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve

In the past years Centers of Excellence (CoE) has risen to prominence as a funding instrument in science. The idea is that by focusing resources, people and attention within a center environment, and over a substantial time span, excellence in science can be promoted. Similarly, interdisciplinarity is often seen as an enabling condition or even necessary for frontier research. This article builds

Scholars in the field of social entrepreneurship are challenging the researchers to produce empirical research on the social dimension of this phenomenon. Drawing on Foucault, this paper proposes the notion of ‘social entrepreneurial rationality’ to capture the social dimension of social entrepreneurship. The article builds on a comparative case study of three social ventures, each adopting a diff

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci assoc

This article develops an analysis of Gender whereby D-gender entersgrammar as a feature variable (edge linker), without a fixed value,either probing n or scanning the context for a value. Only the latterstrategy is available in pronominal gender languages such as English,as they lack n-gender, whereas both strategies are applicable in ngenderlanguages, variably so for variable DPs, depending on th

With decreasing heat demand and less availability of high-temperature heat supply in future energy systems, the current district heating systems may experience increased competition on the heat market. A viable option to mitigate increasing competition is to operate systems with lower temperature levels, and the most conceivable way to achieve lower temperature levels is to decrease return tempera

Today’s society promises that people with disabilities can access anything, but in practice there are numerous obstacles, and the ways in which people deal with them can be easily missed or taken for granted by policy makers. This article draws on a project in which researchers ‘go along’ people with disabilities in Sweden who demonstrate and recount accessibility troubles in urban and digital set

The policy making in internationalisation of higher education is shaped at the national level, and influenced by regional policy debates and globalisation trends, but it tends to obscure the perspectives of academics. Much of what has been written in the scholarly literature in this area has focused on institutional strategies and national policies. We argue that it is crucial to have an in-depth