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The genome is often the conduit through which environmental exposures convey their effects on health and disease. Whilst not all diseases act by directly perturbing the genome, the phenotypic responses are often genetically determined. Hence, whilst diseases are often defined has having differing degrees of genetic determination, genetic and environmental factors are, with few exceptions, insepara
In analysing speeches made by legislators, this book provides theoretical and empirical answers to questions such as: Why do some Members of Parliament (MPs) take the parliamentary floor and speak more than others, and why do some MPs deviate more than others from the ideological position of their party? The authors evaluate their hypotheses on legislative speechmaking by considering parliamentary
Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora o
Reflective practice is seen as a method for professional growth and lasting learning outcomes, but what this means in the context of Higher Music Education (HME) has not received sufficient attention. This paper explores how reflection is ontologised and justified as part of performing musicians’ education. The data utilised derive from a comprehensive project investigating how processes of academ
As a researcher, I have spent countless hours hunting for tags. Recently, I started thinking about ways to represent not just my physical search, but also the thought process taking place alongside the visible bodily activities: remembering – for example – the style, medium, size and placement of previous tags of interest in order to better spot similar tags and their likely locations.This video i
The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with no
Digital technologies have made it easier and more affordable to record, edit and circulate images. At the same time, visuals can provide scholarly insights beyond what may be documented and conveyed in writing. Nevertheless, visual methods still play a secondary role in humanistic and social science research.This book shows how visual methods can be used to approach difficult-to-access fields and
Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are caused by a combination of genetic, environmental and lifestyle factors. This complex etiology creates challenges when it comes to diagnostics, follow-up programs and treatment. Although exact disease mechanisms are yet to be elucidate
How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively an individual awakens in the hours following sleep is not associated with their genetics, but instead, four independent factors: sleep quantity/quali
