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Previous global RNA analysis was restricted to known transcripts in species with a defined transcriptome. Next generation sequencing has transformed transcriptomics by making it possible to analyse expressed genes with an exon level resolution from any tissue in any species without any a priori knowledge of which genes that are being expressed, splice patterns or their nucleotide sequence. In addi
Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancre
The polychaete annelid Kingnites diamondi, a new paulinitid genus and species, is described from the Silurian of Baltoscandia. Its large maxillae differ morphologically from those of all other known paulinitids, particularly in being very elongate and having conspicuous myocoele openings and posterior portions of the first maxillae (MI). Albeit rare, this polychaete taxon is highly characteristic
Within the family of voltage-gated calcium channels (VGCCs), L-type channels (L-VGCCs) represent a well-established therapeutic target for calcium channel blockers, which are widely used to treat hypertension and myocardial ischemia. L-VGCCs outside the cardiovascular system also control key physiological processes such as neuronal plasticity, sensory cell function (e.g. in the inner ear and retin
The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of morbidity and mortality that is attributable to the complications of chronic hyperglycaemia. These complications include blindness, renal failure and cardiovascular disease. Current therapeutic options for chronic hyperglycaemia reduce, but do not eradicate, the risk of these complications. Success in defin
Stage models were prevalent in developmental psychology in the past, but have recently been subjected to much criticism. We propose “rehabilitation”, defining semiotic stage as a (not necessarily stable) period characterized by the clear establishment of a novel semiotic capacity, which may “dominate” the communication of the child at this stage, but does not replace capacities from previous
TV-on-Demand service has become one of the most popular Internet applications that continuously attracts higher user interests. With rapidly increasing user demand, the existing network conditions may not be able to ensure low start-up delay of video playback. Prefetching has been broadly investigated to cope with the start-up latency problem which is also known as user perceived latency. In this
Poor public perception can obstruct a construction project in a damaging way. Knowledge about public opinion should be considered as a relevant area of expertise for project managers and as an essential cost element in the planning and completion of construction projects. A consensual approach to a siting controversy requires informal face-to-face interaction among chosen representatives from all
The paper deals with durability of Self-Compacting Concrete with limestone filler during Thaumasite Sulphate Attack. For this purpose six concrete with varying amounts of limestone filler, particle size of limestone filler, pressure height during casting and mixing order were studied. One normal concrete (without limestone filler) with vibrator compaction was studied in parallel. In the ongoing ex
Based on Brandtler (2012), this paper argues that polarity items are sensitive to evaluability, a concept that refers to the possibility of accepting or rejecting an utterance as true in a communicative exchange. The main distinction is made between evaluable and non-evaluable utterances. The evaluable category comprises any clause that asserts, presupposes or entails the truth of an affirmative o
En solfångarhybrid har utvecklats och utvärderats på avdelningen för Energi och ByggnadsDesign på Lunds Tekniska Högskola, LTH. Solfångarhybriden, ”Solfönstret”, består av solcellslaminerade absorbatorer placerade i ett fönster bakom glasrutorna. Solfönstret finns byggt i ett enfamiljshus, Solgården, i Älvkarleö utanför Gävle. För att minska investeringskostnaderna för solel har reflektorer placer
In order to tap the energy saving and climate mitigation potential of the building sector, transaction costs of implementing energy efficient technologies need to be better understood and ultimately reduced. The objective of this paper is to identify and analyze the nature and scale of transaction costs resulting from the application of the passive house concept in energy efficient renovations. Re
The state of the farming industry in Europe has been put under the spotlight in recent years due to a number of different food scares and disease outbreaks. Many new quality assurance schemes have been formed to accompany the existing environmental monitoring schemes, to give concerned consumers some guarantee when buying food that it is of a good quality and the environmental load of production h
