Purpose: Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking. Methods: We identified 1,340 pa

Objectives: Counts of missing teeth or measures of incident tooth loss are gaining attention as a simple way to measure dental status in large population studies. We explore the meaning of these metrics and how missing teeth might influence other measures of dental status. Methods: An observational study was performed in 2 contrasting adult populations. In total, 62 522 adult participants were ava

Political comedy in various forms is increasingly popular among media audiences, directing scholarly attention to issues like shifting news habits and values, and further, potential impacts on civic cultures. But with the exception of media effects studies, audiences of political com-edy remain largely under-researched (Marchi 2012; Jones 2013).This paper deals with young adult audiences of politi

En stödjande miljö är centralt för att kunna upprätthålla ett självständigt liv och effektivt aktivitetsutförande, särskilt med ökande ålder. För personer med funktionella begränsningar, som konsekvenserna av en ryggmärgsskada, är balansen mellan personens funktionella kapacitet och miljöns krav av yttersta vikt för att kunna leva ett så välfungerande liv som möjligt. Livslängden efter en ryggmärg

We analysed five data sets of night directions of migrating arctic waders ill relation to,winds, recorded by tracking radar and optical range finder, in order to find out if these birds compensate for wind drift, or allow themselves to be drifted by winds. Our purpose was to investigate whether arctic waders use adaptive wind drift strategies or not. The data sets were collected in Siberia (two se

PURPOSE: The aim of this study was to define the scales and test the validity, reliability, and sensitivity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-H&N35, a questionnaire designed to assess the quality of life of head and neck (H&N) cancer patients in conjunction with the general cancer-specific EORTC QLQ-C30. PATIENTS AND

Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni

An energy system that relies on fossil fuel is not sustainable. Emissions, such as carbon dioxide, nitric oxide and corpuscles, affect the climate and pollute the air. Furthermore, the supply of oil, coal and natural gas is located a few places worldwide, which can give rise to geopolitical conflicts for access to these areas. This is not a local issue for Tjörn, nor even a national issue for Swed

Prosthetic loosening, bone graft resorption and osteonecrosis are examples of problems in orthopedic surgery caused by or augmented by bone resorption. Bone resorption is caused by osteoclasts. Osteoclasts can be inactivated with biphosphonates, a drug in clinical use against osteoporosis and osteolytic tumors. The bone resorption-reducing ability of bisphosphonates was analyzed in rat models. An

The serine proteases cathepsin G, leukocyte elastase, proteinase 3, and the inactive protease homologue azurocidin, stored in the azurophil granules of neutrophils, belong to a hematopoietic serine protease superfamily with members in mature effector cells of bone marrow origin. Promonocytic U-937 cells were used for studying the biosynthesis of cathepsin G and leukocyte elastase by biosynthetic r

General characteristics and outcome was evaluated in 177 consecutive patients who underwent a major amputation in a defined population. Smoking and diabetes lowered the mean amputation age. Healing failure at six months was seen in 24% of transtibial and in 11% of transfemoral amputees. Preoperative absence of gangrene and hemoglobin >120 g/L increased the risk of healing failure. Six months after

In this work, various aspects of multivariate monitoring and control of wastewater treatment operation are discussed. A number of important difficulties face operators and process engineers when handling online measurements from wastewater treatment processes. These include, for instance, a high number of correlated measurement variables, non-stationarities, nonlinearities and multiscale process b