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Genetic and non-genetic factors probably act together to initiate and accelerate development of type 1 diabetes [T1D]. One suggested risk factor contributing to development of T1D is air pollution.

In an organization where the safety level is high and incidents and serious accidents are very rare, a steady erosion of safety awareness and protective measures can occur, especially when productive demands rise. Thus, it is important to continuously identify and monitor aspects in the organization that can affect work performance and safety. In an ongoing joint research project between the LFV G

1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. Electron microscopic studies demonstrated an accumulation of CM-Au's both in the

The Baltic Sea is one of the world’s largest brackish water environments and is today suffering from, for example, eutrophication, spreading hypoxia, accumulations of contaminants and invasive organisms. These problems exist due to a combination of natural features that makes the Baltic Sea a sensitive ecosystem (such as long water residence time, limited water exchange, large catchment area), and

Patients waiting for cardiac surgery often consider the period from the decision for surgery to the time for the operation as long, heavy and dreary. Therefore, it is important that patients are supplied with structured oral and written information regarding their disease and its treatment, so that they are able to understand and discuss the forthcoming operation, the risk of complications and the

GBV-C/HGV is a blood-borne virus related to the hepatitis C virus. We studied GBV-C/HGV infection in different populations, its transmission, and its association with liver disease. GBV-C/HGV viraemia was detected by PCR in 19/576 blood donors. Donors with normal and elevated ALT levels had similar rates of viraemia (1.6% vs. 4.1%; p = 0.20). Signs of resolved GBV-C/HGV infection (anti-E2 antibodi

The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. FVIII functions as a cofactor to the enzyme activated factor IX (FIXa) in t

The thesis deals with models for molybdopterin-dependent enzymes. Several model systems containing molybdenum or tungsten have been prepared and characterised, and their reactivity with oxygen atom acceptors and donors have been investigated. Oxygen atom transfer reactions involving oxomolybdenum bis-dithiolene complexes have been modelled using density functional calculations. The first molybden

Research in service management and marketing has in the past decade highlighted the concept of value creation. In service organizations value creation is described as a process in which the customer uses a company's value proposition in a meaningful way. However, research has tended to ignore the contextual meaning, and few empirical studies have shown how context is relevant. Therefore, the aim o

A suicide attempt is one of the most powerful predictors of eventual suicide. The aim of this thesis was to investigate the social situation, including social support of suicide attempters. One part of the investigations concerned patients admitted to a psychiatric ward following a suicide attempt. Another part concerned significant others (SOs) of suicide attempters, interviewed directly after th

The aim with this thesis was to investigate effects of vasoactive mediators on mucociliary activity and blood flow in rabbit and human experimental models. Mucociliary activity in vivo and ciliary beat frequency (CBF) in vitro were measured with photoelectric techniques. Blood flow was measured with laser Doppler flowmetry. Substance P (SP) and methacholine increased human nasal blood flow. Pretre