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BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their
The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six
Most complex diseases have well-established genetic and non-genetic risk factors. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks. Characterizing these gene-environment interactions may help elucidate the biology of complex diseases, as well as to guide strategies
In late modernity, the media is one of the most important social institutions in influencing people's knowledge, perceptions and actions. The media supply citizens with health-related messages and contribute thereby to their health development. The abundant flow of health-related messages, however, makes it difficult for the individual to separate good and reliable information from information of
Abstract Aims: The aim of this thesis was to investigate how the impact of Parkinson’s disease, a chronic neurodegenerative disorder, influences the person’s health-related quality of life. The aim was also to investigate nursing assessment and management of Parkinson’s in elderly persons. Methods: The study started in1998, one year later a follow-up was conducted. The sample contained in the fir
This thesis has synchronization of Multicarrier systems, more specifically Orthogonal Frequency Division Multiplexing (OFDM) systems, as the main theme. The thesis addresses two areas, the first proposing and analyzing time and frequency estimators for OFDM systems, the second investigating more practical issues around these estimators. The practical part addresses implementation and applies the e
BACKGROUND AND PURPOSE: Characteristics of patients receiving total knee arthroplasty (TKA) and prostheses used vary between regions and change with time. How these practice variations influence revision remains unclear. We combined registry data for better understanding of the impact of variation, which could potentially improve revision rates. PATIENTS AND METHODS: We used data from 2003 to 2019
Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Ge
Language experience, particularly from our native language (L1), shapes our perception of other languages around us. The present study examined how L1 experience moulds the initial processing of foreign (L2) tone during acquisition. In particular, we investigated whether learners were able to rapidly forge new neural memory traces for novel tonal words, which was tracked by recording learners’ ERP
Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Met
