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BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Objectives: Individuals with Parkinson's disease (PD) become unavailable in the workforce earlier than comparable members of the general population. This may result in significant social insurance expenses, but as workforce participation can be a source for social interaction and a vital part of the personal identity, there are likely to be personal implications extending far beyond the economic a

Background: Elderly people living in nursing homes (NHs) have multiple diseases as well as risk factors that may complicate optimal medication. Malnutrition and impaired renal function are two of those risk factors. Heart failure is common and may often not be treated or diagnosed adequately in elderly patients.Objectives: The aim of this thesis was to explore different risk factors for elderly wi

Abstract in UndeterminedExtreme down-scaling of nanoelectronic devices by top-down fabrication methods may be hindered by several obstacles, such as the cost for patterning and processing, or inferior device performance due to process-induced damage. In this presentation I will present a bottom-up approach for nanometer-scale device fabrication, based on seeded growth of semiconductor nanowires, u

It is always challenging to try to transmit and transform values and attitudes within a school in a democratic society, and even more challenging to do so in a group of socially disadvantaged pupils. What happens in a classroom where disadvantaged pupils in the upper secondary school meet teachers who have a general obligation to transmit democratic values? This article is a case study of the inte

In this paper we discuss social policy in relation to different development contexts, where characteristics and outcomes of social policies in different sectors ( e.g.,housing, care, education, social security) are compared. The paper relates to the discussion on the causes and outcomes of welfare state management in different contexts. However, existing analytical models do not fit the mixtures

Background: Housing environments that hinder performance of daily activities and impede participation in social life have negative health consequences particularly for the older segment of the population. From a public health perspective accessible housing that supports active and healthy ageing is therefore crucial. The objective of the present study was to make an inventory of environmental barr