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Physical activity and breast cancer. Risk, survival and perceived energy.

Fysisk aktivitet är en hälsofrämjande livsstilsfaktor som minskar risken för flera kroniska sjukdomar såsom hjärt-kärlsjukdomar, diabetes typ 2, depression och vissa typer av cancer. En av cancerformerna där risken minskas är bröstcancer som är den vanligaste cancern hos kvinnor, i Sverige insjuknar ungefär 7 500 kvinnor per år. Bröstcancer kan delas in i olika subgrupper som till viss del styr beBackground: Physical activity and avoidance of sedentariness do enhance health in women with breast cancer, and could even reduce the risk of developing the disease. One aim of this thesis was to elucidate the association between sedentariness and breast cancer risk in women as a whole, and then separately for those younger than 55 years old and those 55 years or older. Two additional aims were re

Measuring adverse events following hip arthroplasty surgery using administrative data without relying on ICD-codes

Introduction Measure and monitor adverse events (AEs) following hip arthroplasty is challenging. The aim of this study was to create a model for measuring AEs after hip arthroplasty using administrative data, such as length of stay and readmissions, with equal or better precision than an ICD-code based model. Materials and methods This study included 1 998 patients operated with an acute or electi

Fasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men

Background: Individuals born with low birth weight (LBW) have an increased risk of metabolic diseases when exposed to diets rich in calories and fat but may respond to fasting in a metabolically preferential manner. We hypothesized that impaired foetal growth is associated with differential regulation of gene expression and epigenetics in metabolic tissues in response to fasting in young adulthood

Increased adherence to treatment guidelines in patients with urinary tract infection in primary care : A retrospective study

Background Urinary tract infection (UTI) is common in primary care and leads to a high number of antibiotic prescriptions. Antimicrobial resistance is a global health problem; better antimicrobial prescribing is one way to limit antimicrobial resistance. We aimed to describe the number of consultations for patients diagnosed with lower urinary tract infection (LUTI) and pyelonephritis and changes

Screening Detects a High Proportion of Celiac Disease in Young HLA-genotyped Children.

BACKGROUND AND AIMS:: Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS:: From a population-based HLA-DQ screening study of newborns born between June 2001 and

Young age at diagnosis is a risk factor for negative late socio-economic effects after acute lymphoblastic leukemia in childhood.

BACKGROUND: The increasing number of survivors after childhood cancer requires characterization of the late complications of these diseases and their treatment. We examined a large number of possible socio-economic late effects following treatment for acute lymphoblastic leukemia (ALL) in order to identify factors leading to a poor outcome. PROCEDURE: All individuals who had been diagnosed with AL

STEPS towards a sustainable plastics system in a circular economy

Plastics are an integrated and important part of the global economy. Plastics have now come under close scrutiny for the ecological impact that their production, widespread use and disposal are having on our planet. Urgent solutions for a more sustainable plastics system are thus being requested, such as increasing their reuse and recycling in a circular economy by improvements in design and produ

Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes

The etiology of type 1 diabetes foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of type 1 diabetes. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) and ZnT8 transporter (ZnT8A) allowed children to be followed from birth until the appearance of a first islet auto

Fracture incidence in Graves' disease : A population-based study

Background Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The ai