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Background Atopic dermatitis (AD) affects health and quality of life (QoL) and also has great impact on both healthcare costs and costs to society. Objectives The aim of the study was to analyse the cost-effectiveness of treatment with tacrolimus ointment vs. standard treatment in patients with moderate to severe AD. Methods A Markov simulation model was constructed capturing several key features
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We reconstruct the Holocene range fluctuations of the European pond turtle (Emys orbicularis) for northern and Central Europe. Based on 529 subfossil records and radiocarbon dating of critical finds, we provide evidence that E. orbicularis experienced a rapid range expansion with Holocene warming. Phylogeographic data argue for a colonization of northern and Central Europe from a glacial refuge lo
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For the last many decades industry and insurance companies have been interested in protecting high racked goods from rapid fire growth. This has mainly been done by installing sprinklers of various types and designs in order to either extinguish the fire or control it. The efficiency of such protection measures is, however, very much dependant on the geometry of the stacks, their height, floor are
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Abstract not available.