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Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study Pediatr Allergy Immunol. 2025;36:e70209. | 1 of 11 https://doi.org/10.1111/pai.70209 wileyonlinelibrary.com/journal/pai Received: 5 February 2025 | Revised: 9 September 2025 | Accepted: 12 September 2025 DOI: 10.1111/pai.70209 O R I
The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2 - dc251198.pdf The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2 Jaakko J. Koskenniemi, Joanna L. Clasen, Lu You, Hemang M. Parikh, Kendra Vehik, Jimin Yang, Ulla Uusitalo, Riitta Veijola, Michael J. Haller, Anette
Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study Distinct Growth Phases in Early Life Associated With the Risk of Type1Diabetes:TheTEDDYStudy Diabetes Care 2020;43:556–562 | https://doi.org/10.2337/dc19-1670 OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-04/116_MP208_Liu_Diab%20Care.%20Growth%20pattern_2020.pdf - 2025-12-24
First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study DOI: 10.2337/dc16-1624 OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/63%2001252019_679_063_MP102_HummelS_Diab%20Care_2017.pdf - 2025-12-24
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children David Endesfelder,1 Wolfgang zu Castell,1,2 Ezio Bonifacio,3,4 Marian Rewers,5 William A. Hagopian,6 Jin‐Xiong She,7 Åke Lernmark,8 Jorma Toppari,9,10 Kendra Vehik,11 Alistair J.K. Williams,12 Liping Yu,5 Beena Akolkar,13 Jeffrey P. Krischer,11 Anette-G. Ziegler,4,14,15,16 and Peter Achenbach
ARTICLE The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study Jeffrey P. Krischer & Kristian F. Lynch & Desmond A. Schatz & Jorma Ilonen & Åke Lernmark & William A. Hagopian & Marian J. Rewers & Jin-Xiong She & Olli G. Simell & Jorma Toppari & Anette-G. Ziegler & Beena Akolkar & Ezio Bonifacio & the TEDDY Study Group Received: 4 September 2014
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_43_krischer_diabetologia_2015.pdf - 2025-12-24
Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study ARTICLE Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study Markus Mattila1,2 & Iris Erlund2,3 & Hye-Seung Lee4 & Sari Niinistö2 & Ulla Uusitalo4 & Carin Andrén Aronsson5 & Sandra Hummel6,7,8 & Hemang Parikh4 & Stephen S. Rich9 & William Hagopian10 & Jorma Toppari11
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter 1Scientific RepoRts | 6:26285 | DOI: 10.1038/srep26285 www.nature.com/scientificreports α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter Oi Wan Wan1,*, Eunju Shin1,*,†, Bengt Mattsson
https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/oiwanwan_et_al_2016.pdf - 2025-12-24
1 Evaluation of the MultiPark Research Infrastructures 2022 Kajsa M. Paulsson, Faculty of Medicine Research Infrastructure coordinator, PhD tumor immunology, Executive Masters in Business Administration (EMBA) Research Infrastructure management Background The strategic research area (SRA) Multidisciplinary research focused on Parkinson´s disease (MultiPark) is one of 11 SRAs where Lund University
Professor Kontaktinformation E-post: erik [dot] swietlicki [at] fysik [dot] lu [dot] se Mobil: +46 70 992 45 12Organisation Förbränningsfysik Hämtställe: 14 WebbplatsErik Swietlickis profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde NanoLund: Centre for Nanoscience Profilområdesmedlem Lunds lasercentrum, LLC Profilområdesmedlem LTH profilområde: Nanovet
https://www.cec.lu.se/sv/erik-swietlicki - 2025-12-24
Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of those aspects. We have investi
Information about extracellular proteolytic activity is transduced to the cell by a transmembrane G-protein coupled receptor subfamily. These receptors are activated by proteolytic cleavage in the extracellular amino-terminal domain and are thus termed proteinase-activated receptors (PARs). The second member of this subfamily, PAR-2, is activated by trypsin-like proteinases, however the physiologi
ABSTRACT Streptococci constitute a heterogeneous group of Gram-positive bacteria, divided into different serological groups on the basis of antigenic differences in a cell wall-associated carbohydrate. This thesis describes related surface proteins expressed by bacteria in two of these groups, the group B streptococcus (GBS) and the group A streptococcus (GAS). GBS is an encapsulated bacterium th
The different steps in the dissolution process of polydisperse polymers in water have been studied. To that end, poly(ethylene oxide), dextran and hydroxypropyl methylcellulose tablets varying widely in polydispersity have been produced by mixing low molecular weight and high molecular weight samples in different proportions. The individual release of the low and high molecular weight fractions ha
The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug
