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Epithelial damage may contribute to the pathology in airway diseases such as asthma and rhinitis. However, the distribution of epithelial shedding in inflammatory airway diseases and, particularly, the ensuing repair processes are largely unknown. In the present studies we have developed novel in vivo techniques to explore epithelial repair mechanisms and associated tissue responses occuring in gu
Type 2 diabetes and the metabolic syndrome are highly prevalent disorders with severe complications such as cardiovascular disease. The aetiology of type 2 diabetes and the metabolic syndrome is not known, but the interaction between genetic factors and environmental triggers is important. The aim this thesis was to identify genetic factors that may increase susceptibility to these disorders by in
Security in organizations is no longer just a matter of having locks and alarms; it is more like a question of different dimensions of rules, perceptions and actions. The focus must return to more interpersonal relationships in security issues instead of technically advanced equipment. In facing today’s challenges, the focus must be on more interpersonal relationships in security issues than on te
Light detection and ranging (lidar), a method for nonintrusive, single-ended, and range resolved measurements, has been developed and applied for combustion related diagnostics. Employing picosecond laser pulse durations and detectors providing temporal resolution on the order of picoseconds, lidar has been applied successfully for both quantitative temperature- and species concentration measureme
The aim of this study was to investigate clinical, pathophysiological and structural aspects of vibration-induced peripheral neuropathy since work with hand-held vibrating tools may lead to progressive neurological and vascular hand symptoms. Symptomatic vibration-exposed men were examined clinically and by neurography, tactilometry, and vibrometry and by measurement of temperature perception thre
This thesis deals with the interactions between superantigens and their receptors. Superantigens are proteins that are secreted by various bacteria, such as Staphylococcus aureus and Streptococcus pyogenes. Superantigens are able to cross-link T cells and antigen presenting cells by binding to the T cell receptor (TCR) and MHC class II. They bind as unprocessed antigens and activate up to 20 % of
The initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. This thesis describes two novel regulatory mechanisms of the dihydropyridine (DHP)-sensitive VOC in smoo
The aim of the thesis was to investigate how different abiotic and biotic parameters may affect microorganisms and the process performance in various biological wastewater treatment systems. The type of carbon source in the influent wastewater may have a profound effect on the composition and the activity of denitrifying activated sludge bacteria in nutrient removal. Of four investigated carbon s
Prostate-specific antigen (PSA) is a worldwide used tool for the diagnosis and monitoring of prostate cancer. It is a serine protease and belongs to the family of glandular kallikreins. Humans have three classical glandular kallikreins, but it has been reported that rodents have many more. Lately, the family has been expanded to contain 12 new genes, KLK4–KLK15, that are situated at the same locus
This thesis examines the representation in visual culture of the Holocaust, the Nazi genocide of European Jewry. It is divided into three main parts, each one focusing on a particular aspect of Holocaust representation. Part 1, "Meaning" (chapter 1-3), begins by considering the important role played by documentary photographs from the concentration camps for the public knowledge and conception of
Angiotensin-converting enzyme (ACE) inhibitors act by decreasing production of angiotensin II and by potentiating the effects of bradykinin by inhibition of its breakdown. Bradykinin exerts part of its effects via vasodilating prostaglandins. Since the cyclooxygenase (COX)-inhibitors, e.g. aspirin and non-steroidal anti-inflammatory drugs, NSAIDs, block the formation of prostaglandins patients may
This thesis intends to provide spectroscopic information which may be of use in the investigation of low-density plasmas. Developed since the 19th century, the spectroscopic approach has proven to be a versatile method for measuring properties in hot gases, such as electron and ion temperatures and densities, the abundance of various elements in the gas, etc. However, such investigations rely on k
The aim of the thesis was to focus on the occupational health risks in dentistry with emphasis on musculoskeletal disorders in the neck and upper limbs and neuropathy in the hands, in relation to exposure to physical workload, vibration and mercury. An increased high frequency of long-lasting and wide-spread musculoskeletal symptoms in the neck and shoulder regions (58-75% during the past 12 mont
In the superposition compound eye each rhabdom (light sensitive unit) receives light through many ommatidial facets, while in the apposition compound eye every rhabdom receives light from a single facet. The superposition design increases photon capture, which is an advantage in dark environments. Despite their advantage in dim light, superposition eyes can sometimes be found in insects that live
This thesis examines factors regulating growth and distribution of emergent plants with focus on effects of oxygen supply to the roots. Greenhouse experiments revealed that P. australis acclimatizes to specific water depths with phenotypic plasticity. These phenotypic responses act to increase growth at specific water depths but may result in decreased tolerance to changed water depth. Oxygen nee
Fuelled by the current demands of the biological sciences, there is today a growing interest in microscale analysis. Miniaturisation of analytical instruments has become a long-standing trend. Miniaturisation offers several advantages, including rapid separation times, high performance and throughput, reduced costs, etc. But the increased surface area to volume ratio can sometimes be a disadvantag
Possible selves are conceptions or images of ourselves in future states or situations. The theory about possible selves used in the present thesis was developed in a social cognitive tradition of research on the self, where the self is seen as a knowledge structure (Markus & Nurius, 1986). Possible selves are parts of this knowledge structure and possible selves are of importance for motivatio
Phosphor Thermometry is a term describing an optical measurement technique for remote temperature sensing. Its working principle is based on the temperature-sensitive emission characteristics of certain ceramic substances termed thermographic phosphors. These inorganic materials can either be coated on objects for surface thermometry or be seeded into the gas phase or into liquid flows as solid pa
LUMES 20 Years, 1997 – 2017 INTERNATIONAL MASTER PROGRAMME IN ENVIRONMENTAL STUDIES AND SUSTAINABILITY SCIENCE 2 3 Foreword The world is facing a plethora of sustainability challenges including gro- wing inequality, coupled with urbanisation, deforestation, water conflicts, food security conflicts and global climate change. LUCSUS has a vision to combine critical scholarship with solution-based ap
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/lumes_yearbook_high_res.pdf - 2026-06-08
