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Chlorinated fatty acids (ClFAs) are the major contributors of extractable, organically bound chlorine in fish lipids. A known anthropogenic source of ClFAs is chlorine bleached pulp production. Additional anthropogenic sources may exist, e.g., chlorine-containing discharge from industrial and house-hold waste and they may also occur naturally. ClFAs have a wide geographic distribution. They have,
Amongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una
This thesis deals with large eddy simulations (LES) of turbulent combustion processes in direct injection internal combustion (IC) engines. Modeling of direct injection IC engine combustion involves modeling of turbulent spray/gas two-phase flow, modeling of chemical reactions of large hydrocarbon fuels and coupling of chemistry with turbulent flows. LES is chosen in this thesis for it capability
Macroporous hydrogels are regarded as interesting materials both within biotechnology and biomedicine due to their properties. These materials can be prepared from a wide range of synthetic or naturally occurring compounds using a number of different techniques for their production. For this thesis, cryostructuring was used to prepare macroporous hydrogels, often named cryogels. The work utilized
The cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhes
Vision is an important source of information for many animals. The lens plays a central role in the visual pathway and hence the ecology of these animals. Fish have spherically shaped crystalline lenses that contain a gradient of refractive index. Like all refracting elements, lens performance depends on the wavelength of the refracted light. This wavelength dependent focusing leads to chromatic a
A sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
It is attractive to integrate a large deformable mirror for adaptive optics into an astronomical telescope rather than using relay optics within an auxiliary instrument. However, the resulting large deformable mirror can be expensive, particularly for extremely large telescopes. We have pursued a low-cost approach using force actuators connected to the back of the deformable mirror through suction
The overall aim of this thesis was to increase our knowledge of the relationship between structure and function of human skeletal muscle, and about factors affecting strength. The ankle dorsiflexor muscles (DF) were chosen as a representative model of human skeletal muscle, and because these muscles have important roles in gait and maintenance of balance. Specific aims in this thesis were: i) to d
Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. The ultimate solution would be induction of tolerance to t
HAMLET (human alpha-lactalbumin made lethal to tumour cells), a protein-lipid complex originally isolated from human milk, induces programmed cell death selectively in tumour cells. It consists of partially unfolded alpha-lactalbumin in complex with oleic acid. It was previously not known if the unfolding of alpha-lactalbumin alone accounts for the activity of HAMLET or if the lipid adds biologica
The inhibitory neuromuscular control of the human and cat lower oesophagus was investigated by morphological, functional, and biochemical methods. A supply of nerve fibres and myenteric cell bodies, containing nitric oxide synthase (NOS), haem oxygenase (HO)-2, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase activating peptide (PACAP) was observed. The highest density of nerve
Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. Among these, papain-like (C1) peptidases are the mostly studied ones. Inhibitors regulate proteolytic activit
CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. The central role of CD40 in the immune system makes it an ideal target for antibody based immunotherapy. This led us to charact
Most terrestrial vertebrates have colour vision, some perceive a less colourful world and others actually discriminate a wider colour spectrum than humans do. Still, we can all make use of the valuable colour information, which is more rigid than just brightness. However, at night when the light is dim, the lack of photons makes colour vision difficult. Nevertheless, some hawkmoths and bees can se
The present study deals with the works of John Rufus, disciple of Peter the Iberian at Gaza. There are three works preserved from him, composed in Greek at the turn of the sixth century, and preserved in Syriac: the Life of Peter the Iberian, the Commemoration of the Death of Theodosius, and the Plerophories. This study reads the hagiographic works of John Rufus in search for the basic ideological
Exitbeskattning i svensk skattelagstiftning uppmärksammades på nytt hösten år 2017, då Skatteverket la fram ett förslag om exitskatt för fysiska personer. Skatteverkets förslag syftar till att förhindra skatteflykt och bevara en välavvägd fördelning av beskattningsrätten. Den föreslagna exitskatten innebär, mycket förenklat, att fysiska personer som i Sverige gjort orealiserade vinster på bolagsan
För att dömas till straffansvar enligt svensk rätt krävs att gärningspersonen uppvisar skuld antingen i form av uppsåt eller oaktsamhet. Straffrättsligt ansvar för våldtäkt förutsätter enligt svensk rätt att gärningspersonen begår gärningen med uppsåt. I våldtäktsbrottmål kan en gärningsperson som misstar sig om en relevant omständighet och alltså begår gärningen utan uppsåt inte dömas till straff
Sverige tillämpar ett formellt arbetsgivarsynsätt avseende 183-dagarsregeln. Bestämmelsen återfinns i lagen (1991:586) om särskild inkomstskatt för utomlands bosatta, SINK. Där stadgas att utomlands bosatta personers ersättning ska undantas från beskattning om särskilda rekvisit är uppfyllda. Personen ska vistas färre än 183 dagar i Sverige och ersättningen betalas ut från en utländsk arbetsgivare
