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Proteomic analysis of bronchoalveolar lavage (BAL) fluid from smokers at risk of developing chronic obstructive pulmonary disease (COPD) and never smokers is described. COPD is currently the world's fourth leading cause of death and its prevalence is increasing. The leading cause of COPD is smoking and an estimated 600 million people in the world suffer from COPD which makes it the world's most co

The business climate of the energy market has been eventful over the last two decades, particularly with the introduction of the deregulated electricity market and promotion of environmental issues. This has subsequently lead to new analysis criteria, influencing both technology requirements and production costs. To be able to manage all the questions that have arisen from this the knowledge of th

Driving patterns, i.e. the speed and acceleration profiles of vehicles affect exhaust emission and fuel consumption considerably. This project was aimed at investigating urban driving patterns by focusing on the following issues: 1) how to measure driving patterns, 2) measures for the description of driving patterns, 3) identification of characteristics of driving patterns that have significant ef

A light Use Efficiency (LUE) model is developed that allows the mapping of total growing season Gross Primary Production (GPP) for the West African Sahel, using the Normalized Difference Vegetation Index (NDVI) together with other data. Image quality may be poor in monthly NDVI maximum value composites as shown by an improved geostatistical noise estimation technique. Quality may be improved by ot

The aim of the dissertation is to study the organized professional process and the spontaneous integrating and unifying process after the discotheque fire in Gothenburg 1998, when 63 young people died. Over a hundred crisis groups and duty centres were opened for the affected people. These groups are composed of representatives of the social services, psychiatry, the churches and voluntary organiz

The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle

This thesis is concerned with crack control due to imposed deformations in concrete structures. The objective of crack control may either be to prevent cracking or to limit the crack widths. The aim here is to increase the knowledge in both fields for some common structures. Five papers are included and the three last concern crack development. Paper I: Friction tests are performed for slabs cast

In the references invoked by a large number of social projects to achieve their goals, one can find rights and justice as central discursive units in a frequently recurring thought model. In several of these projects the result, time after time, is lack of success. But the same right thought model continues to be taken for granted as a point of departure. The repeated wars on poverty in the USA ex

Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. We started with evaluating the subcellular localization of cyc

This book presents an exhaustive and systematic investigation of six representatives of three important periods of New Testament interpretation: Martin Luther, John Calvin, Brooke Foss Westcott, Heinrich Julius Holtzmann, Rudolf Bultmann and Raymond E. Brown. They serve as dialogue partners in an investigation of the notion of God in the Fourth Gospel, a topic that has been called “the neglected f

Autoimmune diseases are dependent on multiple genes and unknown environmental factors. Great efforts in the identification of genes conferring susceptibility to autoimmune diseases like Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS) have recently been rewarding. A few genes have so far been associated to several autoimmune disorders and the understanding of the role of these genes in the pa

The objective of ceramology is to describe pottery craft traditions; the potters, their production, social organisation and the use of the products. Through this the human actions surrounding the pottery are studied. The objective of the research presented in this thesis is to study patterns of contacts between different, contemporary sites within a limited area through a ceramological analysis of

Food production and consumption are key drivers of environmental pressures and essential factors in the promotion and maintenance of health. Production of food occupies more than 1/3 of global land areas and is estimated to be responsible for some 30% of global greenhouse gas emissions. At the same time, we live in a world where nearly one billion people go hungry and even more people suffer from

This thesis describes the possibility of using hydrophobic peptide tags as tools for bioseparation and for the investigation of recombinant proteins. The hydrophobicity of a protein can easily be changed by minor modifications, such as fusions of tyrosine-containing peptides. The fusion tags may also increase both stability and expression of the fusion protein. Furthermore, a protein library with

Two different detection methods for on-line monitoring of substrates and products in ethanol fermentations have been studied. Amperometric biosensors were developed for use as detectors in flow injection or liquid chromatographic (LC) systems. Carbon paste was used as the electrode material and served as the supporting matrix to incorporate the enzymes alcohol oxidase or pyranose oxidase. Hydrogen

Pharmaceuticals are today released into aquatic environments where they can interfere with organisms' biological processes.The general research objective was to analyze how aquatic freshwater organisms are affected by exposure to pharmaceuticals that are categorized by the EU as potential risk factors to the environment (i.e., 17α-Ethinylestradiol (EE2) and diclofenac). The main aim of this thesis

Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). Numerous long-lasting hypoglycemic reactions, which have sometimes been fatal, have been reported and have been difficult to reconsile with an allegedly short elimina

The Earth is a highly complex and dynamic system. Life has shaped the entire planet and evolved in response to living conditions. Ecosystems are heavily affected by climate. Rapidly changing conditions imply considerable stress on several species and ecosystems, as well as to the most dominant species on the planet. The main focus of this thesis is to investigate climate and anthropogenic interac

The research focus in this dissertation has been on success in selling as created in the seller and buyer interaction on and between macro-, meso- and micro levels. Success seen as a value has consequences for the exchange process, since it affects the actor's action in the seller and buyer interaction on different levels in companies. The study of value is limited to success in selling as a value

In this thesis, spectroscopic studies of quantum wells (QWs), quantum wires (QWRs) and quantum dots (QDs) in III-V semiconductors are presented. The electronic structure of these low-dimensional structures have been studied by absorption, photocurrent, electroreflectance, photoluminescence (PL), and photoluminescence excitation (PLE) spectroscopy. The band alignment of GaAs pseudomorphically grow