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Obesity is increasing throughout the world at an epidemic rate, partly due to increased consumption of diets rich in fat and/or sugar. Ghrelin and leptin are hormones, originating from the periphery, involved in the regulation of food intake and of maintaining energy homeostasis. Circulating ghrelin levels increase in times of energy deficiency, such as fasting, signalling hunger whereas circulati
Viruses have developed several strategies to evade the complement system, a part of the immune system. The fourth open reading frame of the human virus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a type 1 transmembrane protein. This contains four complement control protein domains (CCP domains), and is thus structurally similar to human complement inhibitors. We named it KSHV complement
This book offers a theological study of an expression unique in biblical literature concerning the purpose of life: “that you might become sharers in divine nature” (2 Peter 1:4). Following an analysis of the text-immanent features in 2 Peter 1:1—11, the study delineates comparable notions of “sharers in divine nature” in selected writings that were current in the first century and contrasts these
The aim of this thesis project has been to create miniaturized analytical tools that improve sample preparation for the very rapidly growing field of proteomics research. The presented miniaturized analytical tools provide novel and generic analytical solutions, which are highly adaptable for analysis of various low abundant biomolecules. The adaptability and generality of the analytical technolog
Abstract Centering on notation is a characteristic of Western tonal music. The printed scores are expected to provide the necessary information on musical expression. In this study, strategically selected contemporary musicians’ ways of under-standing the printed scores are investigated. All participants are thoroughly familiar with musical practice in Western tonal tradition. The intention is to
This thesis investigates structure-acoustic systems by use of finite element analysis. The systems studied here are limited to those that consist of an enclosed acoustic fluid cavity, which is coupled to a flexible structure and/or a porous sound absorbing material domain. This type of analysis is applicable to a wide range of engineering problems, for example, studying the interior noise in a ve
Capsazepine and similar compounds, capsazepinoids, were shown to be general inhibitors of agonist (leukotriene D4, histamine, acetylcholine, prostaglandin D2) evoked constriction of human small airway preparations. The mechanism of action remains to be elucidated, but established bronchodilator principles, e.g. beta2-adrenoceptor agonism, as well as TRPV1 antagonism were shown to be less likely. F
This thesis presents the developement and verification of cutting force models for multi-toothed cutting processes. The scope of the thesis includes the modelling and measuring of factors that affect the mechanical load variation between individual cutting edges in the process. These factors will for example influence tool life and workpiece quality. The most important factors are; errors in radia
The aim of these studies has been to investigate what information that can be obtained on gel-emulsions with nuclear magnetic resonance, NMR, as the investigating tool. The gel-emulsions are important in many technical applications such as in food products, in cosmetic and pharmaceutical formulations, and in emulsion explosives, just to name a few applications. We have worked with the NMR diffusom
In this thesis a strategy perspective (the resource-based view) is applied to the New Technology-Based Firms (NTBFs) in Science Parks, arguing that the Science Park provides the firms with a set of resources that if used could help them build their resource base and thus develop and grow. Three categories of resources are identified in the Science Park; University related resources, Science Park f
The objective of this thesis is to develop a simulation tool and a method by which robot trajectories, temperature histories, residual stresses and distortion can be analysed and optimized off-line. This was performed by integrating robot simulation software with finite element analysis software. A special interface was created which facilitated information exchange between the two software progra
For people with central visual field loss, eccentric vision is all that they have to rely on. Even for those who learn how to correctly utilize their eccentric vision, it will never be as good as the central for two entirely different reasons: the off-axis optics of the eye can result in large refractive errors, and the low function of the peripheral retina. This thesis deals with the first of the
Carbon fiber reinforced plastic is constantly gaining market shares due to its unique properties. By heating this kind of materials using induction, many new applications occur. The high resistivity and anisotropic properties of carbon fiber composites means there are a number of challenges to overcome. This work emphasizes the key components related to induction heating of complex materials and p
Political Culture and Social Engagement. An ethnological study of everyday parliamentary life in Helsingborg. The goal of my thesis is to, by examining foundational features which support political culture, make visible prerequisites for political engagement. Using diverse everyday situations, the thesis describes how one “does” politics. I follow two committee chairpersons in the municipality of
Glycosaminoglycans (GAGs) are members of a family of polysaccharide structures consisting mostly of repeating disaccharide units. Most GAGs are attached to specific serine residues in proteins to form proteoglycans (PGs). GAGs and PGs show a large and diverse number of biological functions ranging from cell cycle regulation and control of formation of blood vessels to modification of tissue transp
Several optically active organometallic Phe-AAn-Phe peptidomimetics and macrocyclic Phe-(Phe)n peptides have been synthesized by either intra- or intermolecular peptide bond formation of the corresponding bis(amino acid) derivatives. The key bis(amino acid) derivatives were available from an improved multi-step synthetic route, utilising Horner-Wadswort-Emmons olefination of organometallic aldehyd
The aim of this thesis was to analyze the value of pictures in a number of cognitive tasks that are predominantly verbal in nature. Three studies, with three experiments each, are included in the thesis. The first study found automatic interference effects from pictures (facial expressions) on the affective evaluation of words. In the Stroop-like presentation of integrated picture-and-word stimuli
This thesis describes the design, synthesis and evaluation of synthetic inhibitors for the carbohydrate binding proteins called galectins. Potent and selective inhibitors can be used as important research tools in the endeavor to chart the true role of galectins in biological events such as cancer and inflammation and possibly as lead for future galectin targeting drugs. A panel of O-galactosyl a
This thesis concerns different kinds of tunneling based devices all showing negative differential resistance. The thesis is divided in three parts, resonant tunneling transistors, Esaki diodes and coupled zero dimensional systems. The resonant tunneling transistors are GaAs-based vertical field effects transistors, based on a combination of overgrown tungsten gates and double barrier heterostruct
By using ancient texts, medieval documents, philological observations, and archaeological artifacts, scholars have reconstructed a prehistorical world and religion. The people who upheld this culture have been named, inter alia, "Indo-Europeans", "Aryans", "Japhetites" and "Wiros". Yet, these people have not left any texts, no artifacts can with certainty be ascribed to them, nor do we know any in
