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Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). In addition to the previously proposed pharmacophore elements, two steric repulsive regions have been added to the model and t

Phase diagrams of mixed alkylglucoside surfactants, n-nonyl-b-D-glucopyranoside and n-decyl-b-D-glucopyranoside (C9G1 and C10G1) have been examined for the purpose of determining the microstructure surrounding a closed-loop miscibiliyt gap. There are large deuterium isotope effects on the phase diagram. NMR-self diffusion, cryoTEM and TRFQ experiments show the presence of long interconnect network

Friction Stir Welding (FSW) is a modern welding process that joins materials by frictional heat, generated by a rotating tool. Unlike other welding processes, the material never melts, which is beneficial for the weld properties. FSW is already widely adopted in several industries but the applications are limited to simple geometries like straight lines or circular welds, mostly in aluminium. The

The aims of the thesis were to investigate the prevalence of the upper extremity musculoskeletal disorders in female milkers in relation to other occupational groups; to clarify the relationship between disorders and work environment, psychosocial and life style factors; to compare in a prospective study, pain, ache and discomfort reported by a questionnaire with clinical symptoms and sign; to exa

The modified atmosphere packaging (MAP) of vegetables is used with the aim of prolonging the shelf-life of the packaged produce. The packaging material consists of a permeable film and as a result of the respiration of the produce and gas diffusion through the film, the O2 decreases and the CO2 increases inside the package. This thesis has focused on the MAP of broccoli and the effect of the packa

Individual-based determinations of the absorbed dose in radionuclide therapy largely rely on absolute measurement of the activity distribution and its redistribution over time. Scintillation-camera imaging is the most commonly employed measuring technique, applied in planar or SPECT mode, sometimes in combination with structural images from CT. In this thesis, methods for processing and analysis o

The main aim of the present investigation was to highlight middle childhood creativity, and the children’s perspective on creativity, in contrast to many, if not most, studies that investigate creativity from an adult perspective and a scholarly definition. This dissertation consists of two quasi-experimental studies, and one interview study. Study I investigated if, and how, state anxiety, brough

This thesis describes novel methods for the fabrication of nanometer-scale electronic devices, such as single-electron transistors and resonant tunneling diodes, from wire- and dot-shaped building blocks. The first part of the thesis describes the manipulation of metal nanoparticles and carbon nanotubes using an atomic force microscope. Single-electron transistors were realized by moving nanotubes

The relationships of the mammalian infraclass Marsupialia have been investigated by phylogenetic analysis using completely sequenced mitochondrial genomes. The organisation and structure of the marsupial mitochondrial genomes deviates from the general mammalian structure. Several features, not known from other mammalian mitochondrial genomes have been shown to be present in all seven living marsup

This study deals with the problem of how Ukraine has incorporated and made use of the Holocaust and the 1932?1933 famine (Holodomor) in its new national history and historical culture. The investigation departs from the increased interest in and attention devoted to the Holocaust in recent years. Various institutions and actors have brought the mass murder of Europe's Jews forward as an important

The microbial decomposition of chlorinated organic compounds in kraft bleaching plant effluent (KBPE) was studied. An aerobic bacterium, Strain TCA1, able to grow on trichloroacetic acid as the sole source of energy and carbon was isolated and characterized. Cultivations of Strain TCA1 and another bacterium, Strain DCA1, on acetic acid and its chlorinated analogues mono-, di-, and trichloroacetic

The work reported in this thesis involved the development and application of two novel infrared non-linear laser techniques, namely mid-infrared polarization spectroscopy (IRPS) and mid-infrared degenerate four-wave mixing (IR-DFWM) to combustion diagnostics. These two techniques meet the needs of species concentration detection in combustion environments, especially for those species lacking acce

This thesis consists of four independent exploratory research papers contributing to the economic literature on child and adolescent health, and adult educational and labor market outcomes. Each paper considers type 1 diabetes and focuses on onset over a specific age span. An overall conclusion of this thesis is that individuals with type 1 diabetes deviate from peers without diabetes, irrespectiv

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The purpose of the thesis is to shed light on pre-school as an arena for governmentality, where play is a tool for governing the child. The study focuses what in play-situations may become an object of governance and what techniques the teachers use to govern the children when they play. The theoretical framework is the work of Foucault and his perspective on power and knowledge. The empirical stu

In a flexible real-time system, the constraints in available CPU time and memory lead to resource management problems, which must be handled carefully in order to maximize quality of service while avoiding overload. Managing CPU time -- scheduling -- is well studied and dynamic scheduling is widely accepted in the real-time industry. In order to make safe high-level languages, like Java, practical

The subject matter of the present doctoral thesis is the sociology of philosophy, a sub-discipline within the general field of sociology. As the term clearly indicates, the sociology of philosophy concerns the sociological study of philosophy. As this domain is still, to some extent, virgin territory, my thesis is mainly explorative in nature. Viewed as a whole, it aims at investigating what a soc

Gene therapy in the brain is a promising treatment strategy that in the future may be used for several brain disorders, including Parkinson's disease, Alzheimer's disease and lysosomal storage diseases. By introducing a new gene, rather than providing a classical pharmacological drug, gene therapy offers the opportunity to treat neurological disorders by a single intervention. However, gene therap

This thesis considers various aspects of the poverty in Mongolia, including estimations of the actual as well as future-looking poverty, its distributional and growth components, and selected policy impacts on poverty. Chapter two analyzes the inter-relationship between poverty, growth, and inequality in Mongolia, using Living Standard Measurement Survey (LSMS) for 1998 and 2002. The results show

This thesis in islamology shows how Salman Rushdie's novel The Satanic Verses (1988) examines questions concerning religion, nationality, race, and power, compromise and authenticity in a time when different global processes have created new ways of perceiving and relating to different traditions. It examines how The Satanic Verses portrays how people apprehend themselves and others when the condi