Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. Galiellalactone, a fungal metabolite, inhibits STAT3, thus presenting a potential lead for cancer treatment. The inhibition is bel

This thesis examine how farm-dwellers in the Mälaren region during the late Iron Age and early Middle Ages created, transferred, and preserved memory by deliberately placing new houses and graves on the houses and graves of previous generations. Focus is on memory as a social phenomenon and culture-specific resource created by these deliberate practices. The culture-specific element is oral cultur

Pedagogical practice is, in several important considerations, contradictory in character. In this dissertation attenention is drawn towards the field of tension that prevails between pedagogical action, which can be descibed in terms of strategic processes and communicative pedagogical action. While the former places the preconditions for effective knowledge development of the individual at the ce

In this thesis a technique to manipulate nanoparticles with an atomic force microscope (AFM) is presented. Particles in the size range of 5-500 nm could be positioned in arbitrary two-dimensional patterns on different surfaces by mechanically pushing them with the AFM tip. The technique which is material-independent can be applied to any type of nanometer-sized particles or objects that are free t

The P availability and solubility differ between soils and plants seem to have different ways of utilising the P present. The many P fractions present in soil interact and are closely related to another and transformations may easily occur. Due to this more P than the soluble fraction is available to plants. Different plant species utilise the P in soil differently; the relationship between the pl

The purpose of this thesis is to introduce the concept of distinctive competence in a multi-theoretical setting, consisting of the resource-based view, strategic human resource management and organizational learning, in order to develop a theoretical framework for better understanding of the dynamic side of distinctive competence. The empirical part of the study consists of an in-depth case study

The aim of the dissertation is to elucidate Iron Age settlement in southern Halland from two angles: (1) the evidence of antiquities (graves), ground finds of metal and rock, and place-names; (2) the information conveyed by investigations in settlement archaeology. The combined study of graves, ground finds, and place-names shows that the image of southern Halland in the Iron Age differs depending

Since the 1930s female cashew workers have constituted a majority of the registered workers in the South Indian State of Kerala and today number some 200,000. This group challenged the stereotypical view of Third World women because they were organized into unions, worked in the formal sector, and were literate. The background for this thesis has been the ?Kerala Model?, i.e., the political contex

The protein folding and protein design problems are addressed, using coarse-grained models with only two types of amino acids, hydrophobic and hydrophilic. In addition to hydrophobicity forces, the models contain sequence-independent local interactions which are found to strongly influence the thermodynamics of these models. The models are studied using the dynamical-parameter Monte Carlo method.

The main aim of my dissertation is to investigate som conceptions, power relations, and practices in the discourse of youth problems. I have studied some of the actors that are involved in the social constructing of the "juvenile delinquent" such as the police, the judical system, the social service, the media, the general public and last but not least, the young people themselves. The bulk of my

Models for potein folding are developed and applied to peptides and small proteins with both α-helix and β-sheet structure. The energy functions, in which effective hydrophobicity forces and hydrogen bonds are taken to be the two central terms, are sequence-based and deliberately kept simple. The geometric representations of the protein chains are, by contrast, detailed and have torsion angles as

QCD at very high energies is still not very well understood. Difficulties arise from a strong non-linear dynamics and also from nonperturbative physics. Detailed analytic calculations are often only possible either for simple toy models, or for asymptotically high energies. In this thesis we investigate the high energy dynamics, with the goal of finding a realistic, working model for high energy Q

Increasingly cities compete for tourist dollars, shoppers, financial investments, know-how and tax-payers by bolstering the cities images as centers of creativity, innovation, knowledge, art, design and so forth. Accelerated and intensified globalization, technological advances, market deregulations,de-industrializations and socio-economic change have urged cities, especially former industrial cit