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The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes are present in the airways, which correlate with bacteria-induced exacerbations and severity of the disease. Our study investigated whether the interaction of M. catarrhalis with the human granul
Purpose: Fluorescence in situ hybridization (FISH) is the current gold standard assay that provides information related to risk stratification and therapeutic selection for individuals with plasma cell neoplasms. The differential hybridization of FISH probe sets in association with individuals’ genetic ancestry has not been previously reported. Methods: This retrospective study included 1224 bone
Multiple myeloma is characterized by frequent clinical relapses after conventional therapy. Recently, chimeric antigen receptor (CAR) T cells targeting B-cell maturation antigen (BCMA) has been established as a treatment option for patients with relapsed or refractory disease. However, although >70% of patients initially respond to this treatment, clinical relapse and disease progression occur in
Despite the potential of smart home technologies (SHT) to support everyday activities, the implementation rate of such technology in the homes of older adults remains low. The overall aim of this study was to explore factors involved in the decision-making process in adopting SHT among current and future generations of older adults. We also aimed to identify and understand barriers and facilitator
Group A Streptococcus (GAS; Streptococcus pyogenes) is an important bacterial pathogen causing over 700 million superficial infections and around 500.000 deaths due to invasive disease or severe post-infection sequelae yearly. In spite of this major impact on society, there is currently no vaccine available against this bacterium. GAS strains can be separated into >250 distinct emm (M)-types, and
Objectives: In this nationwide cohort study in a Scandinavian setting, we aimed to investigate the magnitude of association between flucloxacillin use and drug-induced liver injury (DILI). Methods: Nationwide cohort study among adults in Sweden, 2006–2018, was conducted. Register data on filled prescriptions, patient characteristics, co-medications, and DILI were linked. All filled prescriptions f
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious manifestation. Complement activation is important in disease development and has also been detected in patients in remission. The reason for increased complemen
Purpose: Recent work has shown MRI is able to measure and quantify signals of phospholipid membrane-bound protons associated with myelin in the human brain. This work seeks to develop an improved technique for characterizing this brain ultrashort- (Formula presented.) component in vivo accounting for (Formula presented.) weighting. Methods: Data from ultrashort echo time scans from 16 healthy volu
There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues. Only a few studies have examined the correlation between respiration in blood and muscle tissue, with small sample sizes and conflicting results. This study investigated the correlation of mitochondrial respiration within and across
Sarcomas represent a broad and heterogenous group of rare tumors. For some subtypes, there arepathognomonic genetic alterations available, while for others such alterations remain to be identified.Especially in entities that harbor large numbers of complex genetic changes, much still remains to beunderstood. One such entity is osteosarcoma, the most common primary bone tumor. Although primarilyaff
Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC) cause gastrointestinal infection and, in severe cases, hemolytic uremic syndrome which may lead to death. There is, to-date, no therapy for this infection. Stx induces ATP release from host cells and ATP signaling mediates its cytotoxic effects. Apyrase cleaves and neutralizes ATP and its effect on Stx and EHEC infection was the
Introduction: Streptococcus pyogenes (group A streptococcus; GAS) is a pathogen causing over half a million deaths annually worldwide. Human immune cells respond to GAS infection by activating the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines that control infection. We investigated the role of C4b-binding protein (C4BP) and factor H (FH) in the inflammasome response to GA
Agonistic CD40 antibodies activate dendritic cells and can expand and activate tumor-specific T cells. Our purpose was to assess the CD40 agonistic antibody ADC-1013 in the clinical setting including intratumoral administration since preclinical studies have indicated that intratumoral is better than intravenous administration. A Phase I, open label, multicenter study was conducted in patients wit
This paper reports findings from a pilot study for the research project SHARP – Shared Reading After Pain Rehabilitation. SHARP explores the feasibility and effect of Shared Reading, a group-based reading intervention, as a way to improve the quality of life for people with chronic non-cancer pain who have undergone a pain rehabilitation programme (5 weeks) at Skåne University Hospital in Sweden.
RNA viruses have gained plenty of attention during recent outbreaks of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus (ZIKV), and Ebola virus. ZIKV is a vector borne Flavivirus that is spread by mosquitoes and it mainly infects neuronal progenitor cells. One hallmark of congenital ZIKV disease is a reduced brain size in fetuses, leading to severe neurological defects. The
Cardoso_et_al-2018-Journal_of_Comparative_Neurology(1).pdf R E S E A R CH AR T I C L E Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats Tiago Cardoso1,2 | Andrew F. Adler1,2 | Bengt Mattsson1,2 | Deirdre B. Hoban1,2 | Sara Nolbrant1,2 | Jenny Nelander Wahlestedt1,2 | Agnete Kirkeby1,3 | Shane Grealis
”Vi får en säker, enhetlig och inkluderande plattform” Lina Leyman Nilsson, Kristianstads kommun Sidan 2 DIN DIGITALA SKOLA På baksidan hittar du mer läsning. VÄND MIG! Aktuellt Samarbete över gränserna med artificiell intelligens Sundsgymnasiet i Vellinge Digitaliseringen är nu på en helt ny nivå Sidan 4Sidan 3 GRUNDSKOLA OCH GYMNASIUM DIN DIGITALA SKOLA GRUNDSKOLA OCH GYMNASIUM 3DIN DIGITALA SKO
https://www.ehl.lu.se/sites/ehl.lu.se/files/2024-01/din-digitala-skola.pdf - 2026-07-24
2026-04-20 Forskningsetiskt tillstånd för forskning som involverar människa - En lathund Denna lathund riktar sig till forskare och doktorander vid Medicinska fakulteten vid Lunds universitet. Skriften är inte utformad för renodlade studentarbeten eller för andra forskningshuvudmäns (t.ex. Region Skåne) verksamheter. Nedan följer huvuddragen gällande det svenska kravet på forskningsetisk prövning
https://www.intramed.lu.se/sites/intramed.lu.se/files/2026-05/Lathund%20etikanso%CC%88kningar.pdf - 2026-07-24
Dnr: U 2023/875 Allmän studieplan för utbildning på forskarnivå i musikpedagogik 1. Identifikation Utbildningens namn och inriktning: Utbildning på forskarnivå i musikpedagogik Kod: KOMUPE00 Omfattning i högskolepoäng: 240 Nivå: Forskarnivå Examensbenämning: Filosofie doktorsexamen i musikpedagogik Engelsk examensbenämning: Doctor of Philosophy in Music Education Planen har antagits av Konstnärlig
