Filetype
Introduction: Multidrug resistance (MDR) has been identified in wound bacterial isolates from Ukrainian war victims treated in Ukraine and across Europe. ILP100, a drug candidate for the treatment of skin wounds, is composed of a Limosilactobacillus reuteri expressing human chemokine CXCL12. In this study, the antimicrobial effects of ILP100 were tested on MDR bacteria isolated from wounds of Ukra
Background: A single learning algorithm can produce deep learning-based image segmentation models that vary in performance purely due to random effects during training. This study assessed the effect of these random performance fluctuations on the reliability of standard methods of comparing segmentation models. Methods: The influence of random effects during training was assessed by running a sin
Popular Abstract in Swedish Antalet människor som insjuknar i cancer (cancerincidensen) runtom i världen ökar, exempelvis i Sverige har antalet diagnosticerade tumörer ökat med i snitt 2.1% per år de senaste 20 åren. Denna ökning förklaras bland annat av vår ökade livslängd och vårt val av livsstil. Trots detta har antalet människor som dör i cancer minskat de senaste 20 åren. Dessa motsägelsefullThe continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. For this purpose, an in-house design recombinant antibody microar
B cell lymphomas (BCLs) are a group of severe cancers, afflicting both men and women at different ages. Gene expression profiling (GEP), have during the latest decades fundamentally contributed to a better classification and biological understanding of the different BCLs. Most studies using GEP have analyzed mRNA from tumor tissue constituted of both tumor cells and non-malignant bystander cells.
Purpose: Ultrahypofractionated (UHF) radiation therapy (RT) has become a treatment alternative for patients with localized prostate cancer. In more advanced cases, seminal vesicles (SVs) are routinely included in the target volume. The Scandinavian HYPO-RT-PC trial, which compared 42.7 Gy in 7 fractions (fr) to conventional fractionation (CF), did not include SVs in the clinical target volume. The
M al m ö A rt A ca de m y 20 14 – 2 01 5 20 14 – 2 01 5 Gertrud Sandqvist Professor of Art Theory and the History of Ideas; Supervisor for the Doctoral Programme Dr. Sarat Maharaj Professor of Visual Art and Knowledge Systems; Supervisor for the Doctoral Programme Dr. Matts Leiderstam Professor of Fine Arts Haegue Yang Professor of Fine Arts Joachim Koester Professor of Fine Arts Emily Wardill
https://www.khm.lu.se/sites/khm.lu.se/files/maa_2015_opslag_mq.pdf - 2026-07-17
Popular Abstract in English Popular Science Abstract In our daily routines, we use products and come across applications that involve mixtures of polymers and small amphiphilic molecules in water, for example detergents, pharmaceutics, foodstuffs, shampoos and paints. Polymers are very large molecules formed by smaller units that are repeated and connected. Amphiphilic molecules contain both one pThe research described in this thesis aims to understand the interactions between cationic poly(amidoamine) (PAMAM) dendrimers and small oppositely charged amphiphiles at the solid-liquid and air-liquid interfaces in relation to the bulk solution behavior. There is high interest in PAMAM dendrimers because they are well-defined polymers with a hierarchical architecture which makes them promising m
During the prolonged course of chronic viral infection there is a continuous reciprocal interaction between the host immune defence system and the viral immunogens, and viral genetic mutations capable of circumventing host immune defence could be selected for. Our observation of increasing prevalence of heterogeneity in the DNA sequence coding for the ‘a1 determinant of HBsAg in patients with pres
Popular Abstract in Swedish Denna avhandling handlar om antikroppar. Antikroppar är proteiner som bildas av vårt immunförsvar för att skydda oss mot farliga ämnen i vår omgivning, som tex bakterier. På grund av antikroppars unika uppbyggnad och funktion utnyttjas ofta dessa på konstgjord väg. De kan injiceras i kroppen för att bota någon sjukdom eller användas på laboratoriet i olika analyser. InnIn vitro generation of antibody fragments of desired specificity and affinity plays an important role since it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications. Furthermore, the kinetic parameters for an antibody-antigen interaction, rather than the affinity, has shown to correlate with biological functions like virus neutralization. This points
Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing t
In October 1998 Stockholm County launched a 3-year vaccination campaign with the 23-valent pneumococcal polysaccharide vaccine (PPV-23) directed towards all elderly persons. We analysed the impact of this campaign on the incidence and serotype distribution of invasive pneumococcal disease (IPD) in Stockholm County, where the vaccine coverage was 36%, as compared to Skane County, where no vaccinati
We present a generic approach for quantitative differential proteomics that reduces data complexity in proteome analysis by automated selection of peptides for MS/MS analysis according to their isotope-labeling ratio. Isotopic reagents were developed that give products which fragment easily to generate a unique pair of signature ions. Using the ion-pair ratio, we show that it is possible to select
Cytokines direct the differentiation of naive CD4(+) T cells into either IFN-gamma-producing T(h)1 cells or IL-4-producing T(h)2 cells. In this study, we analyzed the activation of signal transducer and activator of transcription (STAT)1, STAT3 and STAT5 (together with STAT4 and STAT6), and the expression of the recently identified suppressor of cytokine signalling (SOCS) proteins, in differentiat
CK2, an acronym derived from the misnomer "casein kinase 2", denotes a ubiquitous and extremely pleiotropic Ser/Thr protein kinase, the holoenzyme of which is composed of two catalytic (alpha and/or alpha') and two noncatalytic beta subunits acting as a docking platform and the multifarious functions of which are still incompletely understood. By combining affinity chromatography and mass spectrom
The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of complement. Herein we report that non-small cell lung cancer (NSCLC) cells produce
BACKGROUND: Molecular evolution of carbohydrate binding modules (CBM) is a new approach for the generation of glycan-specific molecular probes. To date, the possibility of performing affinity maturation on CBM has not been investigated. In this study we show that binding characteristics such as affinity can be improved for CBM generated from the CBM4-2 scaffold by using random mutagenesis in combi
A method for detection and genotyping of genital Chlamydia trachomatis infections based on omp1 gene amplification and sequencing was developed. DNA was extracted from urogenital or urine samples using a Chelex-based method, and an approximately 1,100-bp-long fragment from the omp1 gene was directly amplified and sequenced. Genotyping was performed by BLAST similarity search, and phylogenetic tree
Whereas patients with multiple myeloma (MM) have a well-documented susceptibility to infections, this has been less studied in other B-cell disorders, such as Waldenstrom's macroglobulinemia (WM) and monoclonal gammopathy of undetermined significance (MGUS). We investigated the humoral immunity to 24 different pathogens in elderly patients with MM (n = 25), WM (n = 16), and MGUS (n = 18) and in ag
International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation
Vascular disease is differentiated throughout the vascular regions with aorta more prone to dilatation and with peripheral arteries more prone to occlusive disease. In this study, we investigated the diameter and distensibility in the common carotid artery (CCA) and abdominal aorta (AO) in healthy females of varying ages to assess potential differences in the aging process. The diameter and pulsat
