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SUMMARYVaccines work primarily by eliciting antibodies, even when recovery from natural infection depends on cellular immunity. Large efforts have therefore been made to identify microbial antigens that elicit protective antibodies, but these endeavors have encountered major difficulties, as witnessed by the lack of vaccines against many pathogens. This review summarizes accumulating evidence that
Coxsackievirus A24 variant (CVA24v), the main causative agent of acute hemorrhagic conjunctivitis (AHC), can be isolated from both the eyes and lower alimentary tract. However, the molecular features of CVA24v in feces is not well-documented. In this study, we compared the VP1 and 3C sequences of CVA24v strains isolated from feces during AHC epidemics in Cuba in 1997, 2003, and 2008–2009 with thos
Alloimmunization against human platelet antigen (HPA)-1a during pregnancy can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) and severe bleeding in the foetus or newborn and likely depends on several factors. HPA-1a alloimmunization is associated with DRB3*01:01, which is associated with several DR-DQ haplotypes. However, it is not known to what extent these haplotypes contribute to the
Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among Streptococcus pneumoniae isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data
Infection represents an evolutionary arms race between pathogen and host. Thus, scientists find that pathogenic microbes have evolved elegant strategies to manipulate or avoid our immune system, allowing them to persist within the human population. This thesis is largely focused on how bacteria regulate and exploit the type I interferon (IFN) response in infected macrophages – a processes of centr
This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. In Paper I-III antibody repertoires was evaluated and used to dissect virus-induced antibody responses and characterize such antibodies. Furthermore, tools for m
1 Teaterhögskolan i Malmö: Självvärdering 2018 1. Inledning .................................................................................................................................. 3 1.1 Utbildning på grundnivå: särskilda förutsättningar ...................................................................... 6 1.1.1 Metodik .................................................................
https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2020-12/Binder_thm_2018.pdf - 2026-07-22
lum_2007_10 LUM Lunds universitets magasin | Nr 10 | 2007 botanfinal Hur riskfylld är nanotekniken? Svagt intresse för EU-utbyte LUM nr 10 | 2007 LUM nr 10 | 2007 – Hej, vill ni ha julklappar? En tomteklädd student ställer frågan till en grupp nyanlända ira- kiska flyktingar som nyss påbör- jat sina svenskstudier. Det tar lite tid innan det står klart att presen- ten faktiskt är en present, men
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-10-2007.pdf - 2026-07-22
NanoLund Annual Meeting 202 Participants Name Division and/or Organisation Adam Burke Solid State Physics Adamantia Logotheti Dept. Physics & Electrical and Information Technology Akito Watanbe Synchrotron Radiation Research Albin Hedse Chemical Physics Alexandra Lindholm Solid State Physics Alfredo Serafini Solid State Physics Ali Hosseinnia Combustion Physics Anders Kvennefors Solid State Physic
https://www.nano.lu.se/sites/nano.lu.se/files/2022-10/List%20of%20participants_2022.pdf - 2026-07-22
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time q
Nationella forskarskolan om åldrande och hälsa Fastställd av SWEAH:s styrelse 2019-03-27 Verksamhetsberättelse 2018 Nationella forskarskolan om åldrande och hälsa Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2018 2 Innehållsförteckning sida Styrelse 3 Partners 4 Forskarskolans ledning och administration 5 ◦ Pedagogisk arbetsgrupp 6 Anslutna doktorander 6 Disputationer 2018
https://www.sweah.lu.se/sites/sweah.lu.se/files/sweah_verksamhetsberattelse_2018.pdf - 2026-07-22
Responsibility and Delegation Sustainability 14 April 2022 Page 1 of 6 DECISION Reg. no STYR 2022/825 Date 14 April 2022 Vice-Chancellor Responsibility and Delegation in Environmental and Sustainable Development Approved by the Vice-Chancellor on 14 April 2022 1 Purpose This document describes responsibility and delegation in Lund University’s work on environmental and sustainable development. The
Original Research Communications Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study Elin M Hård af Segerstad,1 Xiang Liu,2 Ulla Uusitalo,2 Daniel Agardh,1 and Carin Andrén Aronsson,1 for the TEDDY Study Group 1De
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-02/140%20%20Hard%20af%20Segerstad_AJCN_2022.pdf - 2026-07-22
The antiviral activities of type I IFNs have long been established. However, comparatively little is known of their role in defenses against nonviral pathogens. We examined here the effects of type I IFNs on host resistance against the model pathogenic yeast Cryptococcus neoformans. After intratracheal or i.v. challenge with this fungus, most mice lacking either the IFN-alpha/beta receptor (IFN-al
Further formulations of mometasone furoate are needed for treatment of patients with plaque psoriasis to meet individual patient preferences. This has motivated the development of Ovixan(A (R)) (Galencia, Malmoe, Sweden), a formulation of mometasone furoate with different cosmetic properties than the commonly used formulation, Elocon(A (R)) (Merck [Schering Plough], Whitehouse Station, New Jersey,
The recently described oomycete pathogen Phytophthora pisi causes root rot on pea and faba bean, while the closely related Phytophthora sojae is the causal agent of soybean root and stem rot. Differences in the pathogenicity factor repertoires that enable the two species to have distinct host specificity towards pea and soybean, were studied using tandem mass spectrometry in a global proteome stud
The high-risk Alpha-types of human papillomavirus (HPV) are the causative agent of cervical cancer, which is the second major cause of death among women worldwide. Recent investigations have shown that E7 from the Alpha-papillomavirus HPV-16 interacts with IKK alpha and IKK beta of the IKK complex in the NF-kappa B pathway leading to an attenuation of the activity. There is a possible link between
In cystic fibrosis (CF), colonization of the airways with Pseudomonas aeruginosa is associated with disease deterioration. The mechanism behind the disease progression is not fully understood. The present work shows that the antibacterial chemokine MIG/CXCL9 is present in the airways and in sputum of CF patients. MIG/CXCL9 showed high bactericidal activity against. P. aeruginosa, including some st
Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develo
Interferon gamma (IFN-gamma) has successfully been used in immunotherapy of different experimental tumours. Mechanistically, IFN-gamma has extensive effects on the immune system including release of nitric oxide (NO) by upregulation of the inducible nitric oxide synthase (iNOS). NO has putative immunosuppressive effects but could also play a role in killing of tumour cells. Therefore, the aim of t
