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Cytomegalovirus induces a chronic infection that in normal individuals is controlled by the immune system. In the case of humoral immunity, epitopes, in particular antigenic domain-1, in glycoprotein B have proven to be important for the induction of virus-neutralizing activity. Such antibodies can exert potent virus-neutralizing activity but can also block neutralizing antibodies from binding. Fu
BACKGROUND AND OBJECTIVES: Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID-19 pandemic in 2020 and 2021.MATERIALS AND METHODS: As in prev
Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antiviral defense, pDCs are assumed to play an essential role in this process; however, robust evidence supporting this dogma is scarce. Genetic or pharmacological manipulations that eliminate pDCs or disrupt their interferon production often affect other cells, confounding interpretat
Infectious diseases have had devastating effects on human populations throughout history, but important questions about their origins and past dynamics remain1. To create an archaeogenetic-based spatiotemporal map of human pathogens, we screened shotgun-sequencing data from 1,313 ancient humans covering 37,000 years of Eurasian history. We demonstrate the widespread presence of ancient bacterial,
Gut-associated lymphoid tissues (GALT) represent major sites of adaptive immune priming in the intestine, yet our understanding of human GALT diversity and function remains limited. Here, we used single-cell RNA sequencing, flow cytometry, and confocal laser microscopy to map the fibroblast (FB) landscape of human GALT, including that of Peyer's patches (PP), mucosal isolated lymphoid follicles (M
BACKGROUND: Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi
Today it is generally accepted that the Bacillus Calmette-Guerin (BCG) vaccine protects against childhood tuberculosis (TB) but this immunity wanes with age, resulting in insufficient protection against adult pulmonary TB. Hence, one possible strategy to improve the protective efficacy of the BCG vaccine would be to boost in adulthood. In this study, using the mouse model, we evaluated the ability
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be class
Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally include a SecB-like chaperone that stabilizes the antitoxin by recognizing its chaperone addiction (ChAD) element. TACs mediate antiphage defense, but the mechanisms of viral sensing and restriction are unexplored. We identify two Escherichia
Background and aims: Active aging is the process through which people strive to maintain wellbeing when growing old. Addressing the lack of research on active aging in the context of housing, the aim was to describe active aging among people aged 55 and older considering relocation and investigate whether perceived housing moderates the relationship between functional limitations and active aging.
BACKGROUND: Discrimination may further impede access to medical care for individuals in socially disadvantaged positions. Sociodemographic information and perceived discrimination intersect and define multiple contexts or strata that condition the risk of refraining from seeking physician's care. By applying analysis of individual heterogeneity and discriminatory accuracy (AIHDA) we aimed to impro
The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of pathogen contact is essential for preventing viral spread. Influenza A virus (IAV) in humans preferentially replicates in the upper respiratory tract (URT) but mouse models of infection result in lower respiratory tract infection. Here, we optimize IAV inoc
Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaini
Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to noninvasively disentangle cellular structural features are needed and are a substantial focus of brain research. Diffusion-weighted MRS (dMRS) gives access to diffusion properties of
Microscopy analysis of tumour samples is commonly performed on fixed, thinly sectioned and protein-labelled tissues. However, these examinations do not reveal the intricate three-dimensional structures of tumours, nor enable the detection of aberrant transcripts. Here, we report a method, which we name DIIFCO (for diagnosing in situ immunofluorescence-labelled cleared oncosamples), for the multimo
1. Identifikation och grundläggande uppgifter 1. Kurskod ARK A02 2. Kursens namn Arkeologi, fortsättningskurs 3. Nivå G 4. Högskolepoäng 30 5. Beslutsuppgifter Fastställd av kursplanegruppen för området för humaniora och teologi 2008-03-07 6. Ändringsuppgifter 2. Allmänna uppgifter 1. Huvudområde/n, om tillämpligt Arkeologi 2. Ämne, om tillämpligt Arkeologi 3. Typ av kurs och dess placering i utbi
https://www.ark.lu.se/media/utbildning/dokument/kursplaner/ARKA02.pdf - 2026-07-24
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study ARTICLE Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study Jeffrey P. Krischer1 & Xiang Liu1 & Åke Lernmark2 & William A. Hagopian3 & Marian J. Rewers4 & Jin-Xiong She5 & Jorma Toppari6,7 & Anette-G. Ziegler8 & Beena Ak
https://www.teddy.lu.se/sites/teddy.lu.se/files/2022-11/134MP210_Krischer_Diabetologia_2021.pdf - 2026-07-24
Nutrients control on the productivity of brownified aquatic ecosystems Problem analysis Departments of Physical Geography and Ecosystem Science Lund University Mayra Rulli Supervisors: Martin Berggren (INES, LU) Ann-Kristin Bergström (EMG, UMU) Ryan Sponseller (EMG, UMU) 10th November 2020 Table of Contents 1. Introduction ...........................................................................
https://www.nateko.lu.se/sv/sites/nateko.lu.se.sv/files/mayra_rulli_problem_analysis.pdf - 2026-07-24
1 Lärande i LTH Decembernumret av Lärande i LTH inleds med en text om den pedagogiska utveckling som sker på LTH, samt den strategi; ”Scholarship of Teaching and Learning”, som utvecklingen utgår ifrån. Varje år anordnas en in- ternationell konferens av The International Society for the Scholarship of Teaching and Learning (ISSOTL) där projekt gjorda inom ramen för de pedagogiska kurserna på LTH k
https://www.lth.se/fileadmin/cee/genombrottet/Laerande_i_LTH/Laerande_i_LTH_blad_16.pdf - 2026-06-09
Språk- och litteraturcentrum Litteraturlista FLRA01, Modersmålsundervisning och studiehandledning, 60 högskolepoäng Fastställd av Sektion 3 2019-06-07, reviderad av Styrelsen för Sektion 5, 25-11-27 Delkurs 1: Introduktion till modersmålsundervisning och studiehandledning, 7.5 högskolepoäng Obligatorisk kurslitteratur Ahnborg, Marie-Hélène (2025). På språklig grund - Betänkande av Utredningen om i
https://www.sol.lu.se/media/utbildning/dokument/kurser/FLRA01/20261/FLRA01_Litteraturlista_VT26_1.pdf - 2026-07-05
