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Identification of covalent binding sites of ethyl 2-cyanoacrylate, methyl methacrylate and 2-hydroxyethyl methacrylate in human hemoglobin using LC/MS/MS techniques.

Acrylates are used in vast quantities, for instance in paints, adhesive glues, molding. They are potent contact allergens and known to cause respiratory hypersensitivity and asthma. Here we study ethyl 2-cyanoacrylate (ECA), methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA). There are only limited possibilities to measure the exposure to acrylates, especially for biological monitori

Fracture mapping using seismic amplitude variation with offset and azimuth analysis at the Weyburn CO2 storage site

Cap rock integrity is an essential characteristic of any reservoir to be used for long-term CO 2 storage. Seismic AVOA (amplitude variation with offset and azimuth) techniques have been applied to map HTI anisotropy near the cap rock of the Weyburn field in southeast Saskatchewan, Canada, with the purpose of identifying potential fracture zones that may compromise seal integrity. This analysis, su

Optimal departure decisions of songbirds from an experimental stopover site and the significance of weather

Recent models have worked with the assumption that birds try to minimize either time, energy or predation risk during migration, or some combination of these. The few empirical studies available have suggested that time minimization may be the most common strategy. One way of distinguishing between strategies is to study the departure decisions of migrating birds. We supplied migrating European ro

Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases

A series of azapeptides as potential inhibitors of cysteine proteases were synthesized. Their structures, based on the binding center of cystatins, contain an azaglycine residue (Agly) in place of the evolutionarily conserved glycine residue in the N-terminal part of the enzyme binding region of cystatins. Incorporation of Agly should lead to deactivation of the acyl-enzyme complex formed against

Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin

The effect of strain and transforming growth factor beta on equine tendon fibroblasts (tenocytes) was assessed in vitro. Tenocytes were isolated from flexor and extensor tendons of horses from foetal to 10 years of age. These cells were cultured until confluent on collagen-coated silicone dishes. Cyclic biaxial strain of 9 +/- 1% was applied at 0.5 Hz for 24 hours with or without added TGFbeta1 or

Interpreting canopy development and physiology using a European phenology camera network at flux sites

Plant phenological development is orchestrated through subtle changes in photoperiod, temperature, soil moisture and nutrient availability. Presently, the exact timing of plant development stages and their response to climate and management practices are crudely represented in land surface models. As visual observations of phenology are laborious, there is a need to supplement long-term observatio

Applying concurrent engineering in an established multi-site companya concurrent process for a developing and manufacturing company’s new product introduction in production.

Background As new product development is becoming more important due to higher and more global competition the new product introduction process needs to be efficient in order to launch new products before they become obsolete. Therefore, a more efficient development process with integrated functions is needed. Concurrent engineering claims to be this and has support in much research. However, conc

Detection of Archaeological Sites from Aerial Imagery using Deep Learning

In recent years, Deep Learning has proven to be an outstanding tool in the field of computer vision showing promising results in different fields such as the analysis of medical images, obstacle detection for self-driving cars, automatic image caption generation, etc. In the case of Archaeology, the adoption of these methods in the detection of archaeological structures from aerial images has been

A Search for Neonicotinoid Binding Sites in the Optic Lobes of Honeybees and Blowflies

Neonicotinoid insecticides are agonists to nicotinic acetylcholine receptors (nAChRs) in the brains of insects. At sub-lethal doses these chemicals cause behavioral abnormalities in several bee species, reducing overall fitness. nAChRs expressed in the optic lobes of insects bind neonicotinoids, thus may be involved in these behavioral changes. Here we attempted without success to visualize the pr

Mortuary Practices in LC Cyprus. A Comparative Study Between Tombs at Hala Sultan Tekke and Other LC Bronze Age Sites in Cyprus

This thesis investigates differences and similarities in the funerary material of Late Bronze Age Cyprus in order to answer questions about a possible uniqueness of the pit/well tombs at the Late Bronze Age harbour city of Hala Sultan Tekke. The thesis also tries to explain why these features stand out as singular, compared to the more common chamber tomb, and the reason for their existence. The t

Site characterisation at the Äspö Hard Rock Laboratory through seismic refraction

The successful construction of any well-functioning structure is dependent on a good understanding of the ground on which it lies. Several methods and techniques have been developed to model subsurface conditions and properties with the purpose of gaining comprehensive knowledge of geological conditions. Seismic refraction presents a geophysical method of subsurface investigation capable of provid

A critical analysis of the alternative energy-poverty discourse with a case of Kasese district in Uganda: New sites, actors, identities, language, and visions of power

One of the central themes in recent sustainable Development debates is the idea that alternative energy technological solutions can also alleviate poverty in parts of the global South. This idea is earmarked in this study as the alternative energy-poverty discourse. Drawing on Critical Discourse Analysis and Post-development theory; the study questions the extent to which the premise of this disco