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Ligand induced activation of the beta-receptor for platelet-derived growth factor (PDGF) leads to activation of Src family tyrosine kinases. We have explored the possibility that the receptor itself is a substrate for Src. We show that Tyr934 in the kinase domain of the PDGF receptor is phosphorylated by Src. Cell lines expressing a beta-receptor mutant, in which Tyr934 was replaced with a phenyal
Background/Aims: We have observed a difference between patients on low-flux hemodialysis (HD) or peritoneal dialysis and patients on hemodiafiltration (HDF) or high-flux HD in the capacity of transmigrated leukocytes to mobilize CD11b in response to inflammatory stimuli compared with healthy subjects. This could be due to different interstitial chemokine concentrations. Methods: We measured concen
-Reduced arterial compliance precedes changes in blood pressure, which may be mediated through alterations in vessel wall matrix composition. We investigated the effect of the collagen type I-alpha1 gene (COL1A1) +2046G>T polymorphism on arterial compliance in healthy individuals. We recruited 489 subjects (251 men and 238 women; mean age, 22.6+/-1.6 years). COL1A1 genotypes were determined using
The effect of strain and transforming growth factor beta on equine tendon fibroblasts (tenocytes) was assessed in vitro. Tenocytes were isolated from flexor and extensor tendons of horses from foetal to 10 years of age. These cells were cultured until confluent on collagen-coated silicone dishes. Cyclic biaxial strain of 9 +/- 1% was applied at 0.5 Hz for 24 hours with or without added TGFbeta1 or
Each autumn, large numbers of red admirals migrate throughout northern Europe,flying south, to reach areas with conditions suitable for surviving the winter. We observed the visible butterfly migration at Falsterbo peninsula, the southwesternmost point in Sweden, where red admirals are seen most autumns. ying towards the Danish coast on their way to more southern parts of Europe. Weather parameter
Particle formation events were analysed from aerosol number size distribution data collected at a background station in southern Sweden between February 2001 and May 2004. Events occurred on about 36% of all days and were favoured by high global radiation values. The clearest events (class I, 20% of all days) were observed when the formation rate of activated hypothetical clusters around 1 nm diam
Bakteriella infektioner är ett stort globalt hälsoproblem och mer detaljerad kunskap om värd-bakterieinteraktioner är nödvändiga för att kunna bemöta den ökande antibiotikaresistensen. Nordenfelt-labbet använder unik biosensorteknologi tillsammans med avancerad videomikroskopi och bildanalystekniker för att studera tidiga värd-bakterieinteraktioner. Den molekylära sammansättningen av bakterier ochBacterial infections represent a major global health issue and more detailed knowledge about host-bacteria interactions are needed to counteract the rising bacterial resistance to antibiotics. The Nordenfelt Lab uses unique biosensor technology in conjunction with advanced live imaging and image analysis techniques to study initial host-pathogen interactions. The molecular surface composition of
Environmental psychology conducts research, teaching and collaborations focused on the interaction between people and the environment from the perspective of the individual. The subject deals with how people experience their surroundings and are affected by them, as well as how humans affect the environment through their behaviour. The research encompasses the relationship to both the physical a
Deux filles sont autour d'une table sur laquelle est posée une carte d'Italie. L'une d'elles est blonde, avec cheveux bouclés, et porte une robe verte, et l'autre a des cheveux brunes attachés en deux couettes, et porte une robe bleue. La première est assez ronde tandis que l'autre est mince comme une aiguille. Deux tasses de café (ou de thé, ou de chocolat, ou de cappuccino...) sont posées sur la
