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The late-Holocene decline of Tilia in relation to climate and human activities - pollen evidence from 42 sites in southern Sweden

Aim: The dominant role of Tilia in primeval forests of Scandinavia has long been recognized, but the timing and mechanisms for its decline have not been completely unravelled. A particular uncertainty involves the balance between climate and human activities as the drivers of the change. One reason for the uncertainty is the challenge in evaluating the past cover of the genus owing to its poorly d

Dynamics of Aromatic Side Chains in the Active Site of FKBP12

Defining and applying surrogate safety measures and behavioural indicators through site-based observations

Site-selective ¹³C labeling of histidine and tryptophan using ribose

Role of adenine and guanine sites in hole hopping in dna nanowire

Transfer integrals for oligos with different bases have been calculated using INDO/Koopman's approximation to unveil the charge transport mechanism in DNA. The sequences, G(A)nG, n = 1, 2, …, 10; G(A)xG(A)yG, x + y = 9; and G(A)xG(A)yG(A)zG, x + y + z = 8, were employed to interpret the Guanine (G) and Adenine(A) hopping. Adenine hopping is found to be faster in G(A)nG sequences with longer Adenin

Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120

Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if present, the resolving Cys (CR). A detailed catalytic cycle has been derived for typical 2-Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs. We have

A microgel-Pickering emulsion route to colloidal molecules with temperature-tunable interaction sites

Ischemia-induced upregulation of excitatory amino acid transport sites

Return to Antikythera : Multi-Session SLAM based AUV mapping of a first century BC wreck site

This paper describes an expedition to map a first century B.C. ship wreck off the coast of the Greek island of Antikythera using an Autonomous Underwater Vehicle (AUV) equipped with a high-resolution stereo imaging system. The wreck, first discovered in 1900, has yielded a wealth of important historical artefacts from two previous interventions, including the renowned Antikythera mechanism. The de

The Solution Structures of Mutant Calbindin D_9k's, As Determined by NMR, Show That the Calcium-Binding Site Can Adopt Different Folds

Hydride binding to the active site of [FeFe]-hydrogenase

Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase

Identification of an endothelial cell binding site on kininogen domain D3

Mapping the cell binding site on high molecular weight kininogen domain 5

Shortcomings in current practices for decision-making process and contaminated sites remediation

Heterogeneity of benzodiazepine receptor interactions with γ-aminobutyric acid and barbiturate receptor sites

Perturbation of benzodiazepine receptor binding by pyrazolopyridines involves picrotoxinin/barbiturate receptor sites

Dihydropicrotoxinin binding sites in mammalian brain : Interaction with convulsant and depressant benzodiazepines

The specific binding of [3H]α-dihydropicrotoxinin to rat brain membranes was inhibited competitively and potently (IC50 ≅ 100 nM) by a convulsant benzodiazepine drug, RO5-3663. This compound did not inhibit high affinity flunitrazepam binding to the same tissue under similar conditions, and its reported pharmacological activity as an antagonist of GABAergic synaptic transmission, which resembles t

Barbiturate receptor sites are coupled to benzodiazepine receptors

Picrotoxin and convulsant binding sites in mammalian brain