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The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. At low concentrations of denaturant the transition state occurs early in the folding reaction, whereas at high denaturant concentration it moves close to the nati
Denna uppsats kommer att belysa Gula Västarna-rörelsen som just nu pågår runt om i Europa, med fokus på Frankrike och Belgien. Uppsatsen ska förklara varför dessa rörelser har uppstått, om de är typiska demonstrationer och om EU är en av huvudanledningarna till att den spridit sig runt om i just Europa. Den kommer även belysa hur detta missnöje uttrycker sig av demonstranterna. Uppsatsen kommer, m
A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th
Free heterogeneous argon-krypton clusters have been produced by coexpansion and investigated by means of x-ray photoelectron spectroscopy. By examining cluster surface and bulk binding energy shifts, relative intensities, and peak widths, we show that in the mixed argon-krypton clusters the krypton atoms favor the bulk and argon atoms are pushed to the surface. Furthermore, we show that krypton at
The use of algae as a feedstock for the production of advanced biofuels has tremendous potential because of its short growth cycle, high productivity, lack of competition for agricultural lands, ability to use a variety of water sources and recycle CO2 and nutrient emissions, and compatibility with existing fuels chains with minimum process changes. However, to make significant contributions to bi
Contemporary debates on sustainability usually relies on standardised and normative categories, such as ‘social’ and ‘nature’, and on linear notions of time. This study explores a more complex perspective on the delicate borderlands between the ‘un-sustainable’ and the ‘sustainable’. A particular material and a particular place stand at the centre of attention: woollen Merino fibre on the South Am
Familial risks for histopathology-specific cancers have not been determined. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 1 million tumors to calculate standardized incidence ratios (SIRs) for familial cancers of specific histology and morphology among 0- to 66-year-old offspring. We used histology codes for both offspring and parents, but because of the li
