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BACKGROUND: Little is known about the factors that predict for gastrointestinal stromal tumor (GIST) recurrence in patients treated with adjuvant imatinib. METHODS: Risk factors for GIST recurrence were identified, and 2 risk stratification scores were developed using the database of the Scandinavian Sarcoma Group (SSG) XVIII trial, where 358 patients with high-risk GIST with no overt metastases w
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious varian
The preferences of some woodland understorey species for ammonium and nitrate were investigated by measuring the potential nitrification (conversion of ammonium to nitrate) in the rhizosphere compared with the bulk soil. Less acid-tolerant species, which usually prefer nitrate or a mixture of ammonium and nitrate in hydroponic culture, should have a higher potential nitrification in the rhizospher
The binding of factor IX to cultured bovine endothelial cells was characterized using isolated domains of bovine factor IX. An NH2-terminal fragment that consists of the gamma-carboxyglutamic acid (Gla) region linked to the two epidermal growth factor (EGF)-like domains bound to the endothelial cells with the same affinity as intact factor IX, indicating that the serine protease part of factor IX
Objective: To develop an enzyme linked immunosorbent assay (ELISA) to quantify the levels of specific aggrecan fragments generated by aggrecanase-mediated cleavage at the (373)Glu-(374)Ala bond within the aggrecan interglobular domain. Methods: The ELISA employs a commercially available monoclonal antibody to capture aggrecan fragments containing keratan sulfate (KS). Aggrecan fragments generated
We present a new method for quantification of the coupling efficiency between amphiphilic oligonucleotides and suspended small unilamellar lipid vesicles (SUVs). The method employs a supported (phospho) lipid bilayer (SLB)-modified sensor template, which upon exposure to a mixture of SUVs and amphiphilic DNA reacts neither with free SUVs nor with DNA-modified SUVs, but with free DNA only. Using ca
Previous cytogenetic and comparative genomic hybridization (CGH) analyses have shown that the gain of chromosome arm 12p is frequent in pancreatic carcinomas. We investigated 15 pancreatic carcinoma cell lines using CGH, fluorescence in situ hybridization (FISH), and semiquantitative polymerase chain reaction (PCR) to characterize 12p amplifications in detail. The CGH analysis revealed gains of 12
The DNA ploidy level of 673 accessions belonging to 238 species of Hieracium have been analyzed by flow cytometry. 222 of the species were of Scandinavian origin as members of the exclusively apomictic H. sectt. Bifida, Hieracium, Oreadea, Tridentata and Vulgata. For the overwhelming majority of the species, the ploidy level (or chromosme number) has never been investigated before. Approximately 5
Denna rapport är skriven inom kursen ”VBRN70 - Brandteknisk riskvärdering” vid Lunds Tekniska Högskola. Rapporten omfattar en brand- och utrymningsanalys av Kungliga Dramatiska Teatern i Stockholm med fokus på personsäkerhet. Analysen inleddes med ett platsbesök för att få bättre kännedom om objektet. Utifrån observationer från platsbesöket och tillgänglig statistik identifierades därefter flerta
Det kommunala planmonopolet tillåter våra kommuner att reglera mark- och vattenanvändningen samt hur bebyggelsen ska se ut. Detta innebär en stor frihet för kommunens sida men även ett stort ansvar att hantera bygglovsansökningar på ett ansvarsfullt sätt. Det är viktigt att kommunen på ett korrekt och legitimt sätt tar hänsyn till de lagar och regler som en bygglovsprövning innefattar. Åtgärden soMunicipalities have a planning monopoly that allows them to regulate land and water use. With this follows a responsibility to handle building permits in a responsible manner. The building measure must abide by the detailed development plan. Sometimes the building measure deviates from the plan, in such cases the Building committee of the municipality can grant a building permit with a minor devia
Purpose: The purpose of this research is to contribute to logistics research arena in management practices using qualitative methods. Because previous research paradigm has been dominated by quantitative methods, where managerial work practices have been neglected or understated. Hence, by using the qualitative method the study can enrich the importance of manager work practice in logistics and br
Tropical forests are of great importance to all living-beings due to their high biodiversity and the valu-able resources, such as food and fuel, they provide. In addition, tropical trees sequester a high amount of carbon and consequently over half of the global forest carbon stock can be found in the tropics. Climate change, however, might weaken this carbon sink and possibly result in tropical fo
Today cities are the result of centuries of history and human development, accelerated during the past 100 years. Post-industrialization, modernism’s top-down city planning approach, and the prioritisation of motor vehicle design over humans resulted in more people moving to cities, more space needed to allocate new vehicles, expansion over rural areas, and exponential pollution growth. Thus, huma
Title: Multi-Sided Platforms: Understanding their strengths and weaknesses Seminar date: 2014-05-22 Course: FEKN90 Företagsekonomi: Examensarbete på Civilekonomprogrammet (30 ECTS) Authors: Lucas Ehrenstråhle and Elin Mathies Supervisor: Magnus Johansson Five keywords: MSP, activities, resources, differentiation and platforms The purpose: is to investigate why small actors use multi-sided pl
This study investigates how lead content and bioavailability in soil affects growth and root/shoot ratio in three commonly cultivated species: wheat (Triticum turgidum), clover (Trifolium) and radish (Raphanus sativus). The study investigates the levels at which soil lead content contribute to toxic effects in plants, and when it may pose a risk to consumers. In addition, lead accumulation and the
Communication today is not something merely taking place face to face, technology such as the internet and social media channels have opened up for endless interactions taking place in the online world. User generated content in the form of online travel reviews come with many challenges and opportunities for organizations. User generated content has been shown to impact a travelers decision in al
