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The Veiki moraine in northern Sweden, a geomorphologically distinct landscape of ice-walled lake plains, has been interpreted to represent the former margin of an intermediate-sized pre–Last Glacial Maximum (LGM) Fennoscandian ice sheet, but its age is debated as either marine isotope stage (MIS) 5c or MIS 3. We have applied optically stimulated luminescence (OSL) and radiocarbon dating to four si

BackgroundConcerns around staffs’ and students’ interactions with commercial entities, for example drug companies, have led several North American medical schools to implement conflict of interest (COI) policies. However, little is known about COI policies at European medical schools. We analysed the content and strength of COI policies at Scandinavian medical schools.MethodsWe searched the websit

The COVID-19 accelerated shift towards hybrid workspaces places major pressure onworkplace communities and culture. This study explores the emergence of a collaborative academic workspace, which is still in the real estate development phase. The aim is to establish preconditions for community building, and the relationship between the community and the physical space. The study employs a qualitati

Epilepsy is a severe neurological disease manifested by spontaneous recurrent seizures due to abnormal hyper-synchronization of neuronal activity. Epilepsy affects about 1% of the population and up to 40% of patients experience seizures that are resistant to currently available drugs, thus highlighting an urgent need for novel treatments. In this regard, anti-inflammatory drugs emerged as potentia

Bacterial adhesion to the host is the most decisive step in infections. Trimeric autotransporter adhesins (TAA) are important pathogenicity factors of Gram-negative bacteria. The prototypic TAA Bartonella adhesin A (BadA) from human-pathogenic Bartonella henselae mediates bacterial adherence to endothelial cells (ECs) and extracellular matrix proteins. Here, we determined the interaction between B

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B

BACKGROUND: Asthma is the most frequent chronic disease in children. One of the most replicated genetic findings in childhood asthma is the ORMDL3 gene confirmed in several GWA studies in several paediatric populations.OBJECTIVES: The purpose of this study was to analyse ORMDL3 variants and expression in childhood asthma in the Polish population.MATERIALS AND METHODS: In the study we included 416

Introduction: High-mobility group box 1 (HMGB1) is a non-histone nuclear protein and can be extracellularly secreted to induce sterile inflammation. Although uterine deletion of HMGB1 causes implantation and decidualization defects, how secreted HMGB1 is involved in mouse early pregnancy is still unknown. Methods: Mouse models, mouse primary endometrial cells and human endometrial cell lines were

The design of port complexes is a process that requires considering geographical and economic features of the territory. It is necessary to aggregate the characteristics of coastal landscapes, seascapes, artificial elements, dangerous objects, etc. The experience of implementing such projects (for example, in Sabetta) suggests that all participants in the design process need highly precise geograp

This study focusses on the urban infrastructure for water supply in Roman Pompeii. The water distribution network of lead pipes was constructed inside the city walls, at the time when the city was connected to an aqueduct. Life for the Pompeiians changed considerably when aqueduct water started running continuously in street fountains all around the city. The study is based on previous research an

Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the

Cancer is one of the leading causes of death worldwide, but reliable diagnosis and staging can contribute to optimal treatment planning, and is a crucial factor in reducing mortality and maintaining quality of life. Soft tissue mechanical properties are promising indicators of cancer that can be assessed non-invasively using functional imaging. Additionally, lymphatic involvement is considered a k

Respiration in animals, plants and many bacteria is dependent on heme A, which functions as a prosthetic group in a-type cytochromes (terminal energy-transducing oxidases in the electron transport chain that reduce molecular oxygen to water). Heme A synthase catalyses a chemically very demanding reaction, the conversion of one specific methyl side-group of heme O to a formyl group of heme A. This

Every year about 15 million people are injured in traffic, 500,000 of these fatally. Developing countries are badly affected. During the worst years of the war in Nicaragua, more people died in traffic accidents than as a direct result of the war. Transport system and infrastructure have developed rapidly in developing countries, while little has been achieved in preventing accidents or lessening

Keynote paper The point of departure for this lecture lies in the insight that tourism research is uniquely positioned at the juncture of applied and scholarly research. Drawing upon work I have conducted in the realms tourism and leisure study, the lecture strives to problematize the practice of ethnography as a method and raise questions concerning the opportunity research in the fields of tour