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Popular Abstract in Swedish INTRODUKTION Aminosyror är en grupp små molekyler som finns i våra celler. Totalt finns det tjugo olika aminosyror, vilka kan binda till varandra i långa kedjor varvid de bildar proteiner (äggviteämnen). Proteiner ansvarar för en lång rad funktioner i organismen och varje cell i en organism måste därför kunna syntetisera ett par tusen olika proteiner för att kroppen ska1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indica

Popular Abstract in Swedish Forskning kring biomarkörer har revolutionerat cancersjukvården. Några av de mest kända exemplen är PSA-testet som kan användas för att identifiera patienter med ökad risk för prostata cancer eller de nya antikroppsbehandlingarna, t.ex mot HER2 (trastuzumab/Hercepin) eller CD20 (rituximab/Rituxan), som gör att man nu ofta kan förlänga eller bota patienter som tidigare hThe goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. The aim of this thesis is to

INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis, but earlier tumor detection would improve survival. We aimed to develop and externally validate a risk prediction model based on exposure to readily available risk factors to identify high-risk individuals of ESCC.METHODS: Competing risk regression modeling was used to develop a risk prediction model. Individuals' ab

BACKGROUND AND OBJECTIVE: Nonmetastatic (M0) clear cell renal cell carcinoma (ccRCC) recurs in ∼20% of patients within 5 yr after surgery. With no biomarkers available, recurrence detection relies on radiological imaging. Urine glycosaminoglycan profiles (GAGomes) were previously associated with M0 ccRCC recurrence. We conducted an observational prospective multicentre diagnostic test cohort study

When patients experience peripheral vestibular or certain central disorders causing dizziness or vertigo, this is sometimes associated with experiencing also disrupted spatial orientation, which may be accentuated by exposure to a distorted visual environment. This study explores the impact of sensorimotor factors and sex on spatial orientation in sitting and standing positions. In the Rod-and-Fra

The effects of high hydrostatic pressure (up to 8 kbar) on bacteriochlorophyll a Qy electronic absorption bands of LH2 photosynthetic antenna complexes have been studied at ambient temperature. A variety of samples were studied, including intact membranes and isolated complexes from wild type and mutant photosynthetic bacteria Rhodobacter sphaeroides, Rhodopseudomonas acidophila, and Rhodospirillu

Populärvetenskaplig sammanfattning: Vinderosion på jordbruksmark har länge varit ett välkänt faktum trots att någon utförligare undersökning om dess omfattning och skadeverkan inte tidigare genomförts. Mot bakgrund av detta har därför ett nordeuropeiskt projekt, WEELS (Wind Erosion on European Light Soils), dragits i gång som syftar till kartlägga vinderosionen på sandig jordbruksmark i norra Euro

Tre borrkärnor bestående av sjösediment, vardera 1.5 meter långa, från Byestadsjön i Småland, Sverige studerades med hjälp av mineralmagnetiska- kol- pollen- och röntgenflourosens (XRF)- analyser. Målet med studien var att rekonstruera tidig Holocen miljö, med fokus på tiden mellan 9000-7000 år sedan och därmed avgöra om det kalla klimatåterslaget cirka 8200 före nutid påverkade regionen eller ej.Three sediment cores, each 1.5 meters in length, obtained from Lake Byestadsjön in the province of Småland, southern Sweden were studied with high resolution mineral magnetic measurements, carbon content, pollen analysis and XRF analysis. The aim was to reconstruct the early Holocene environment, with focus on the period between 9000-7000 cal yr BP, and thereby conclude if the 8200 cal yr BP cooli

“Comparing Apples & Oranges – A Life Cycle Perspective on the Energy Requirements in Swedish and British Columbian Building Codes” The requirements to decrease the energy use in a building vary in the building codes. “British Columbia Building Code” (BCBC) prescribes a nominal thermal resistance of insulation, while “Boverket’s Building Regulations” (BBR) requires an annual specific energy use

Under de senaste 100-200 åren har tall (Pinus sylvestris) etablerats på många sydsvenska mos- sar. Eftersom tall trivs i relativt torra och näringsrika miljöer, ger detta en indikation på att grundvattennivån i mos- sarna har sänkts. Tre mossar i Kronobergs län, Småland, har valts ut för en dendrokronologisk och torvstratigrafisk undersökning för att se om det finns ytnära torvlager som vittnar omScots pine (Pinus sylvestris) can be found growing in many raised bogs in Småland, south Sweden, and these trees have been established during the last 100-200 years. Because pine prefers a relatively dry environment rich in nutrients, its presence indicates a lowering of the groundwater table. Three bogs in south Sweden were in- vestigated with dendrochronologic and peat stratigraphic methods to d

En sedimenttransekt bestående av tio punkter borrades med hjälp av en ryssborr i alkärret vid Kalvöviken på Biskopsmålahalvön i centrala Blekinge. I huvudpunkten togs tre parallella 1 m långa borrkärnor. Sedimentprov togs ur borrkärnorna och undersöktes med hjälp av glödförlust, mineralmagnetiska-, makrofossil-, pollen- och strukturanalyser. Kronologin fastställdes genom två kol-14-dateringar kompA sediment transect based on ten corings were performed with a Russian peat corer in the aldercarr at Kalvöviken on the Biskopsmåla Peninsula in central Blekinge. Three parallel sediment cores were collected at the master coring point. These cores were subsampled and studied by means of loss of ignition (LOI), mineral magnetic measurements, macrofossil analysis, pollen analysis and structural anal

The research objective for this thesis are two problematic yet interweaving occurrences observed in earlier research on the Abu Ghraib scandal (2004) and its image material. Firstly in terms of methodology, a restricted amount of images in which three single images, “Hooded Man”, “Man on Leash” and “Piled Bodies” are overrepresented and frequently regarded as descriptive for the scandal as such. S

The ETS family transcription factor GABPA is suggested as an oncogenic element, which is further supported by the recent reporting of it as the sole ETS member to activate the mutant TERT promoter in thyroid carcinomas (TC). However, it remains unclear how GABPA contributes to TC pathogenesis. The present study is designed to address this issue. TERT expression was significantly diminished in TERT

Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing mu

Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient isc

Quality of Life and long-term clinical outcome following robot-assisted radical trachelectomy. Objectives: To evaluate quality of life (QoL) and long-term clinical outcome following robot-assisted radical trachelectomy (RRT). Study Design: Prospectively retrieved clinical data were rereviewed on all women planned for a fertility sparing RRT for early stage cervical cancer at Skåne University Hospi

Background: Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation,

The standard prognostic marker for multiple myeloma (MM) patients is the revised International Staging System (R-ISS). However, there is room for improvement in guiding treatment. This applies particularly to older patients, in whom the benefit/risk ratio is reduced because of comorbidities and subsequent side effects. We hypothesized that adding gene-expression data to R-ISS would generate a stro