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MicroRNAs are small single stranded RNA molecules containing approximately 22 nucleotides and these play an important regulatory role in gene expression. MicroRNAs are found to be involved in several diseases and knowledge about their sequences can be an important tool in the foundation of novel treatment methods against diseases. Today, these small RNA molecules are mainly analyzed with qPCR and
The research objective for this thesis are two problematic yet interweaving occurrences observed in earlier research on the Abu Ghraib scandal (2004) and its image material. Firstly in terms of methodology, a restricted amount of images in which three single images, “Hooded Man”, “Man on Leash” and “Piled Bodies” are overrepresented and frequently regarded as descriptive for the scandal as such. S
Hazardous substances i.e., substances of concern pose a risk to both human health and the environment. Stricter regulations and increased focus on circular economy are pushing organisations to substitute hazardous chemicals to safer alternatives. Substitution can lead to a number of benefits, for example cost reductions and competitive advantages. There has been a growing focus on substitution sin
Large and old trees provide important habitat structures and support a high diversity of species. Habitat continuity and landscape connectivity is crucial for species associated with oaks. Fragmentation, agriculture intensification and changed forest management has caused a reduction of old and large oaks, which threatens the long-term persistence of oak associated species by reducing habitat cont
Bygg- och fastighetssektorn står för stora utsläpp av växthusgaser från byggnadsmaterial- och energianvändning. Byggbranschen står idag för ca en femtedel av Sveriges totala koldioxidutsläpp. Ett område med stor potential är byggnadsmaterial där IsoTimber är ett av företagen som driver utvecklingen framåt. IsoTimber är en relativt ny aktör inom byggsektorn som tillverkar prefabricerade väggar i trThe construction and real estate sector accounts for a large part of the emission of greenhouse gases from the usage of building material and energy. The construction industry today accounts for about one-fifth of Sweden’s total carbon dioxide emissions. One area with great potential is building materials where IsoTimber is one of the companies that drive the development forward. IsoTimber is a re
All around the world is the form of the built environment playing a significant role in either enabling or inhibiting outdoor activities. When it comes to winter and Winter cities, it is a challenge how to enable and encourage outdoor activities and soft mobility as the harsh conditions often make it uncomfortable to spend longer periods of time outdoors. A major urban design challenge in Winter
Pancreatic polypeptide (PP) is a gut-derived hormone of the neuropeptide Y family that regulates appetite, gastrointestinal motility, and energy homeostasis through activation of the neuropeptide Y4 receptor (Y4R). With the rising prevalence of obesity, understanding the molecular pharmacology and structure-function relationships of PP-Y4R interactions is essential for the development of novel ant
Through the tight link between plants and their pollinators, plant species often decline when their pollinators decline and vice versa. These nominal declines are well studied for many plant-pollinator networks. Less well known is the effect that the decline of a plant species has on the behaviour of its pollinators, and how potential changes in pollinator behaviour affect the reproductive success
Selectivity control of aniline oxidation and low reactant conversion in traditional synthesis methods are great challenges, and it is desirable to develop a green, low-cost and highly efficient catalytic route toward value-added products. Herein, an Rb-promoted Fe/CeO2 nanocatalyst was prepared to understand the effects of Rb-promoter on the catalytic performance for the selective oxidation of ani
Due to the large-scale production of lignin, continuous flow reactors are preferred for its further valorization through depolymerization. However, there is limited literature on their use in lignin depolymerization, especially concerning feedstock pretreatments and catalyst deactivation. Therefore, in this study, the impact of a batch solvolysis pretreatment on the mild reductive catalytic depoly
Due to ongoing climate change, methane (CH4) emissions from vegetated wetlands are projected to increase during the 21st century, challenging climate mitigation efforts aimed at limiting global warming. However, despite reports of rising emission trends, a comprehensive evaluation and attribution of recent changes remains limited. Here we assessed global wetland CH4 emissions from 2000-2020 based
Tumors with anaplastic lymphoma kinase (ALK) fusion rearrangements, including non-small-cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. Although mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been dis
Dune slacks are biodiverse seasonal wetlands within sand dune systems, strongly influenced by the dynamics of the local groundwater regime. Future climate predictions indicate strong adverse impact on the hydrology and therefore ecology of these wetland ecosystems. In this study we aimed to find the most appropriate hydrological and ecological indicators to summarise dune slack plant community res
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis, but earlier tumor detection would improve survival. We aimed to develop and externally validate a risk prediction model based on exposure to readily available risk factors to identify high-risk individuals of ESCC.METHODS: Competing risk regression modeling was used to develop a risk prediction model. Individuals' ab
Despite the importance of mineral-associated organic matter (MAOM) in long-term soil carbon (C) and nitrogen (N) persistence, and the significant contribution of fungal necromass to this pool, the factors controlling the formation of fungal-derived MAOM remain unclear. This study investigated how fungal necromass chemistry, specifically melanin, interacts with soil mineral properties and microbial
This study inventories, classifies, and evaluates the hydrological heritage of North Macedonia, categorizing key features into four main groups: (1) river basins, including rivers and waterfalls; (2) springs, classified as karst and thermal; (3) natural lakes, subdivided into tectonic, glacial, landslide, denudation, and karst types; and (4) marshes. Recent measurements have shown a significant de
The effects of high hydrostatic pressure (up to 8 kbar) on bacteriochlorophyll a Qy electronic absorption bands of LH2 photosynthetic antenna complexes have been studied at ambient temperature. A variety of samples were studied, including intact membranes and isolated complexes from wild type and mutant photosynthetic bacteria Rhodobacter sphaeroides, Rhodopseudomonas acidophila, and Rhodospirillu
