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Bacterial colonization of the lower respiratory tract is frequently seen in COPD and may cause exacerbations leading to deterioration of the disease. An important part of the innate lung immunity is antimicrobial peptides, not least the cathelicidin hCAP-18/LL-37. Peptidylarginine deiminases (PADI) posttranslationally modifies proteins by converting cationic peptidylarginine residues to neutral pe

Aliphatic compounds on plant surfaces, called epicuticular waxes, are the first line of defense against pathogens and pests, contribute to reducing water loss and determine other important phenotypes. Aliphatics can form crystals affecting light refraction, resulting in a color change and allowing identification of mutants in their synthesis or transport. The present study discloses three such Ece

Numerous genetic factors that influence breast cancer risk are known. However, approximately two-thirds of the overall familial risk remain unexplained. To determine whether some of the missing heritability is due to rare variants conferring high to moderate risk, we tested for an association between the c.5791C>T nonsense mutation (p.Arg1931*; rs144567652) in exon 22 of FANCM gene and breast canc

Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), s

A 30-m-thick sedimentary succession at Leinstranda on the southwestern coast of Br circle divide ggerhalv circle divide ya, northwestern Svalbard, spans the two last glacial-interglacial cycles and reveals information on glacial dynamics, sea-level changes and the timing of these events. We investigated the deposits using standard stratigraphical and sedimentological techniques, together with grou

A first research development progress report of the Chromosome 19 Consortium with members from Sweden, Norway, Spain, USA, China and India, a part of the Chromosome-Centric Human Proteome Project (C-HPP) global initiative is presented (http://www.c-hpp.org). From the chromosome 19 peptide-targeted library constituting 6159 peptides, a pilot study was conducted using a sub-set with 125 isotope-labe

Life-threatening intracardiac and great vessels thrombi are rare in neonates. Recombinant tissue plasminogen activator (rTPA) is used in adults to stimulate fibrinolysis and facilitate thrombus resolution. Its use in neonates, along with heparin, remains controversial because of potential risk of serious bleeding. We aim to present our experience with the use of thrombolytic agents in seven neonat

OBJECTIVES: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.

Colonies of N-2-fixing cyanobacteria are key players in supplying new nitrogen to the ocean, but the biological fate of this fixed nitrogen remains poorly constrained. Here, we report on aerobic and anaerobic microbial nitrogen transformation processes that co-occur within millimetre-sized cyanobacterial aggregates (Nodularia spumigena) collected in aerated surface waters in the Baltic Sea. Microe

Aim of the study: The primary purpose of this study is to investigate if pretreatment plasma levels of vascular endothelial growth factor (VEGF) are predictive of the effect of celecoxib on survival in advanced non-small cell lung cancer (NSCLC) treated with palliative chemotherapy. A secondary objective is to describe the course of plasma VEGF levels during and after treatment with cytotoxic chem

BackgroundPost-relapse survival (PRS) was evaluated in patients with Ewing sarcoma (EWS) enrolled in chemotherapy protocols based on the use of high-dose chemotherapy with busulfan and melfalan (HDT) as a first-line consolidation treatment in high-risk patients. ProcedureEWS patients enrolled in ISG/SSG III and IV trials who relapsed after complete remission were included in the analysis. At recur

Loop migration among birds is characterized by the spring route lying consistently west or east of the autumn route. The existence of loops has been explained by general wind conditions or seasonal differences in habitat distribution. Loop migration has predominantly been studied at the population level, for example by analysing ring recoveries. Here we study loop migration of individual marsh har

In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by exchange-mediated orientational randomization (EMOR) of intra- and intermolecular magnetic dipole-dipole couplings. We have embarked on a systematic program to develop, from the stochastic Liouville equation, a general and rigorous theory that c

En sedimenttransekt bestående av tio punkter borrades med hjälp av en ryssborr i alkärret vid Kalvöviken på Biskopsmålahalvön i centrala Blekinge. I huvudpunkten togs tre parallella 1 m långa borrkärnor. Sedimentprov togs ur borrkärnorna och undersöktes med hjälp av glödförlust, mineralmagnetiska-, makrofossil-, pollen- och strukturanalyser. Kronologin fastställdes genom två kol-14-dateringar kompA sediment transect based on ten corings were performed with a Russian peat corer in the aldercarr at Kalvöviken on the Biskopsmåla Peninsula in central Blekinge. Three parallel sediment cores were collected at the master coring point. These cores were subsampled and studied by means of loss of ignition (LOI), mineral magnetic measurements, macrofossil analysis, pollen analysis and structural anal

Syftet med studien är att utforska hur personer hanterar sin självpresentation på sociala nätverkssidor. Fokus ligger på hur användare förhåller sig till en heterogen publik samt hur sociala normer och det upplevda risktagandet påverkar beteendet och självpresentationen på olika digitala forum. Studien har utförts med hjälp av en kvalitativ metod och empirin består av tre fokusgruppintervjuer med

Amningsfrekvensen i Sverige och övriga västvärlden har under flera år varit sjunkande. Den nedåtgående trenden kan delvis bero på förändrade attityder till amning. Syftet med studien var att mäta föräldrars attityder till amning dagarna efter förlossningen, med målet att nå en högre förståelse för vilka variabler som påverkar dessa attityder. Detta är en tvärsnittsstudie baserad på Iowa Infant Fee

Globaliseringen av kulturen, ekonomin och politiken leder till gränsöverskridande interaktioner för många aktörer mellan regioner och länder. I takt med att kommunikationen blir allt snabbare och når allt fler platser ökar kontakten mellan människor och ger ögonblickligen information om händelser från alla jordens hörn. Nya innovationer och medicinska genombrott stärker livskvaliteten och ökar livThe globalization of culture, economy and politics leads to cross-border interactions of actors across regions and countries. As communication gets faster and reaching more places contact between people is increasing and information on events from every corner of the world is accessible. New innovations and medical breakthroughs will strengthen the quality of life and increase life expectancy for