Search results

Purpose: Caveolin-1 (CAV1) has been implicated in breast cancer oncogenesis and metastasis and may be a potential prognosticator, especially for non-distant events. CAV1 functions as a master regulator of membrane transport and cell signaling. Several CAV1 SNPs have been linked to multiple cancers, but the prognostic impact of CAV1 SNPs in breast cancer remains unclear. Here, we investigated CAV1

Introduction: Proton radiation therapy (PT) has become a treatment option alongside photon therapy (XRT) for lower-grade gliomas (LGG). In this single-institution retrospective study, we investigate the patient characteristics and treatment outcomes, including pseudo-progression (PsP), for LGG patients selected for PT. Method: Adult patients with grade 2–3 glioma consecutively treated with radioth

An association between high Galectin-4 (Gal-4) and prevalence of diabetes in subjects with heart failure (HF) has previously been reported. The purpose of this study was to confirm these findings, as well as to further investigate this association, in a Swedish HF population. In addition, a second aim was to explore Gal-4’s association with obesity and biomarkers of metabolism and heart failure. G

Background:Sensory overresponsivity (SOR) has emerged as a potential endophenotype in obsessive-compulsive disorder (OCD), but few studies have examined SOR in relation to the major symptom dimensions of OCD and to symptoms across the full obsessive-compulsive (OC) symptom spectrum.Objective:This study had 2 main objectives. First, we examined the psychometric properties of the SOR Scales in a com

OBJECTIVE: To investigate potential risk factors behind the increased incidence of necrotising enterocolitis (NEC) in Swedish extremely preterm infants.DESIGN: Registry data from two population-based national cohorts were studied. NEC diagnoses (Bell stage ≥II) were validated against hospital records.PATIENTS: All liveborn infants <27 weeks of gestation 2004-2007 (n=704) and 2014-2016 (n=895) in S

BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.METHOD

Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family mem

Background: Synaptic dysfunction and degeneration are central contributors to the pathogenesis and progression of parkinsonian disorders. Therefore, identification and validation of biomarkers reflecting pathological synaptic alterations are greatly needed and could be used in prognostic assessment and to monitor treatment effects. Objective: To explore candidate biomarkers of synaptic dysfunction

Aim: Understanding how climate conditions influence plant–pollinator interactions at the global scale is crucial to understand how pollinator communities and ecosystem function respond to environmental change. Here, we investigate whether climate drives differences in network roles of the main insect pollinator orders: Diptera, Coleoptera, Lepidoptera and Hymenoptera. Location: Global. Time period

The EU Biodiversity strategy aims to plant 3 billion trees by 2030, in order to improve ecosystem restoration and biodiversity. Here, we compute the land area that would be required to support this number of newly planted trees by taking account of different tree species and planting regimes across the EU member states. We find that 3 billion trees would require a total land area of between 0.81 a

BACKGROUND: Triglyceride-glucose (TyG) index is a useful low-cost marker of insulin resistance. We aimed to evaluate the association between TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality in two large prospective Swedish cohorts, the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CV) and the Malmö Preven

Industrial biotechnology has been defined as the use and application of biotechnology for the sustainable processing and production of chemicals, materials and fuels. It makes use of biocatalysts such as microbial communities, whole-cell microorganisms or purified enzymes. Although biocatalysts are considered advantageous, since they operate under mild conditions regarding temperature and pH and e

This licentiate thesis in industrial design concerns the challenge and opportunity to meet the demographic changes and the future senior market. The aim is to explore how various user-centered design methods can be combined, modified and practiced to create conditions for the design of totally new or improved products. Design is understood as a process to develop solutions with the starting point

De senaste årtiondenas teknologiska utveckling har haft en stor inverkan på journalistbranschen. Inte minst har sättet nyheter produceras och konsumeras förändrats i grunden. Fler aktörer tävlar om konsumenter på ett fält där journalister tidigare haft ett relativt ohotat informationsmonopol. En konsekvens är att journalistbranschen har kommersialiserats, vilket gjort att läsare jagas på ett nytt

Delar av den postmoderna konsumentforskningen argumenterar för att forskare måste byta perspektiv från ett modernistiskt till ett postmodernt synsätt vid studier av konsumenter och konsumtion. Detta postmoderna perspektiv beskrivs av Firat och Venkatesh (1995) genom fem postmoderna konsumtionsvillkor. Villkoren redogör för en fragmenterad individ som vill konsumera utifrån egna förutsättningar samParts of the postmodern consumer research argue that researchers must change their perspective from a modernist to a postmodern point of view when studying consumers and consumption. This postmodern perspective is described by Firat and Venkatesh (1995) through five conditions of postmodern consumption. These conditions describe a fragmented individual who wants to consume on his or hers own premi

Uppsatsen “Är engagemang framtidens valuta? En studie av social valuta” är skriven i Medie- och kommunikationsvetenskap vid Institutionen för kommunikation och medier, Lunds Universitet, under hösten 2014. Uppsatsen behandlar användningen av fenomenet social valuta vid marknadsföring samt redogör får dess förutsättningar och konsekvenser. Social valuta är ett i stort sett outforskat ämne men är en

Uppsatsen ämnar besvara hur företag arbetar för och rapporterar om verksamhetens jämställdhetsarbete, samt varför de väljer att offentliggöra verksamhetsarbetet genom hållbarhetsrapporter. För att besvara frågorna har såväl primär som sekundär data använts. En kvalitativ undersökning har genomförts av författarna, där information från 10 privatägda företag från olika branscher samlats in och sammaThe purpose of this essay is to examine how enterprises work towards greater gender equality and how they report about their work. It also aims to analyze why enterprises choose to compile these activities and measurements into official reports. In order to answer the questions asked in the essay, both primary and secondary data has been used. A qualitative survey has been conducted, where the aut